Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Piperazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | PDE4A | P27815 | 1/20 | 0.50 |
| ▸ | KDR | P35968 | 1/20 | 0.50 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 3/20 | 0.32 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.32 |
| ▸ | RGS12 | O14924 | 1/20 | 0.32 |
| ▸ | GABRR1 | P24046 | 1/20 | 0.32 |
| ▸ | GABRR2 | P28476 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | BLM | P54132 | 1/20 | 0.32 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.32 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Piperazine SCHEMBL5053500 | 1.00 | HIF1A (0.50) | HIF1AMAPTPDE4AKDRCXCR4 | |
| Piperazine SCHEMBL28128235 | 1.00 | HIF1A (0.50) | HIF1AMAPTPDE4AKDRCXCR4 | |
| Piperazine SCHEMBL27815540 | 1.00 | HIF1A (0.50) | HIF1AMAPTPDE4AKDRCXCR4 | |
| Piperazine SCHEMBL27826049 | 1.00 | HIF1A (0.50) | HIF1AMAPTPDE4AKDRCXCR4 | |
| Piperazine SCHEMBL2783137 | 1.00 | HIF1A (0.50) | HIF1AMAPTPDE4AKDRCXCR4 | |
| Piperazine SCHEMBL23235242 | 1.00 | HIF1A (0.50) | HIF1AMAPTPDE4AKDRCXCR4 | |
| Piperazine SCHEMBL1972873 | 0.96 | HIF1A (0.46) | HIF1AMAPTPDE4AKDRCXCR4 | |
| Piperazine SCHEMBL15364207 | 0.96 | HIF1A (0.46) | HIF1AMAPTPDE4AKDRCXCR4 | |
| Piperazine SCHEMBL15363813 | 0.96 | HIF1A (0.46) | HIF1AMAPTPDE4AKDRCXCR4 | |
| Piperazine SCHEMBL28092756 | 0.96 | HIF1A (0.46) | HIF1AMAPTPDE4AKDRCXCR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 2486 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-122011579-A | Fluorine-free halogen-free flame retardant polypropylene composition and preparation method and application thereof | 金发科技股份有限公司 | 2026-05-12 | — | — | CN | claimed |
| CN-122011578-A | Fluorine-free halogen-free flame retardant polypropylene composition and preparation method and application thereof | 金发科技股份有限公司 | 2026-05-12 | — | — | CN | claimed |
| US-20260115979-A1 | FOAM MATERIAL WITH THERMAL INSULATION, FLAME RESISTANCE AND EMI SHIELDING | INT AUTOMOTIVE COMPONENTS GROUP NA INC (US) | 2026-04-30 | — | — | US | claimed |
| US-20260092163-A1 | FLAME-RETARDANT COMPOSITION, FLAME-RETARDANT RESIN COMPOSITION, AND MOLDED PRODUCT | ADEKA CORPORATION (JP) | 2026-04-02 | — | — | US | claimed |
| CN-118620324-B | Halogen-free ablation-resistant polypropylene resin composition and application thereof | 金发科技股份有限公司 | 2026-02-27 | — | — | CN | claimed |
| US-12540229-B2 | Flame-retardant composition and flame-retardant synthetic resin composition | ADEKA CORPORATION (JP) | 2026-02-03 | — | — | US | claimed |
| EP-4638573-A1 | FLAME RESISTANT FOAMED ARTICLE | SABIC Global Technologies B.V. (NL) | 2025-10-29 | — | — | EP | claimed |
| EP-4632041-A1 | FLAME-RETARDANT COMPOSITION, FLAME-RETARDANT RESIN COMPOSITION AND MOLDED ARTICLE | ADEKA CORPORATION (JP) | 2025-10-15 | — | — | EP | claimed |
| EP-4130197-B1 | FLAME RETARDANT COMPOSITION, FLAME-RESISTANT SYNTHETIC RESIN COMPOSITION, AND MOLDED BODY | ADEKA CORP (JP) | 2025-10-01 | — | — | EP | claimed |
| CN-120158029-A | Polypropylene composition and preparation method and application thereof | 金发科技股份有限公司 | 2025-06-17 | — | — | CN | claimed |
| US-20040209982-A1 | Foams expanding in a fire | INTUMEX GMBH (AT) | 2004-10-21 | — | — | US | claimed |
| EP-1469059-A2 | Expandable foams in case of fire | INTUMEX GmbH (AT) | 2004-10-20 | — | — | EP | claimed |
| US-20040185097-A1 | Controlled release modifying complex and pharmaceutical compositions thereof | GLENMARK PHARMACEUTICALS LTD. | 2004-09-23 | — | — | US | claimed |
| WO-2004066910-A2 | CONTROLLED RELEASE MODIFYING COMPLEX AND PHARMACEUTICAL COMPOSITIONS THEREOF | GLENMARK PHARMACEUTICALS LTD. (US) | 2004-08-12 | — | — | WO | claimed |
| US-20030191078-A1 | Inhibition of infectious agents by exogenous oligonucleotides | HYBRIDON, INC. | 2003-10-09 | — | — | US | claimed |
| US-20030186911-A1 | Inhibition of infectious agents by exogenous oligonucleotides | HYBRIDON, INC. | 2003-10-02 | — | — | US | claimed |
| CN-1397590-A | Flame retardant synthetic resin compsn. | ASAHI DENKI KOGYO (JP) | 2003-02-19 | — | — | CN | claimed |
| EP-0882091-A1 | UNSATURATED POLYESTER RESINS FLAME RETARDED BY MELAMINE AND PHOSPHORUS COMPOUNDS | DSM N.V. (NL) | 1998-12-09 | — | — | EP | claimed |
| US-5811547-A | Method for inducing crystalline state transition in medicinal substance | NIPPON SHINYAJU CO., LTD. (JP) | 1998-09-22 | — | — | US | claimed |
| WO-1997031056-A1 | UNSATURATED POLYESTER RESINS FLAME RETARDED BY MELAMINE AND PHOSPHORUS COMPOUNDS | DSM N.V. (NL) | 1997-08-28 | — | — | WO | claimed |