Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Piperazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | PDE4A | P27815 | 1/20 | 0.50 |
| ▸ | KDR | P35968 | 1/20 | 0.50 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 3/20 | 0.32 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.32 |
| ▸ | RGS12 | O14924 | 1/20 | 0.32 |
| ▸ | GABRR1 | P24046 | 1/20 | 0.32 |
| ▸ | GABRR2 | P28476 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | BLM | P54132 | 1/20 | 0.32 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.32 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Piperazine SCHEMBL28128235 | 1.00 | HIF1A (0.50) | HIF1AMAPTPDE4AKDRCXCR4 | |
| Piperazine SCHEMBL27815540 | 1.00 | HIF1A (0.50) | HIF1AMAPTPDE4AKDRCXCR4 | |
| Piperazine SCHEMBL27826049 | 1.00 | HIF1A (0.50) | HIF1AMAPTPDE4AKDRCXCR4 | |
| Piperazine SCHEMBL2783137 | 1.00 | HIF1A (0.50) | HIF1AMAPTPDE4AKDRCXCR4 | |
| Piperazine SCHEMBL227947 | 1.00 | HIF1A (0.50) | HIF1AMAPTPDE4AKDRCXCR4 | |
| Piperazine SCHEMBL23235242 | 1.00 | HIF1A (0.50) | HIF1AMAPTPDE4AKDRCXCR4 | |
| Piperazine SCHEMBL1972873 | 0.96 | HIF1A (0.46) | HIF1AMAPTPDE4AKDRCXCR4 | |
| Piperazine SCHEMBL15364207 | 0.96 | HIF1A (0.46) | HIF1AMAPTPDE4AKDRCXCR4 | |
| Piperazine SCHEMBL15363813 | 0.96 | HIF1A (0.46) | HIF1AMAPTPDE4AKDRCXCR4 | |
| Piperazine SCHEMBL28092756 | 0.96 | HIF1A (0.46) | HIF1AMAPTPDE4AKDRCXCR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1328610-B1 | PHOSPHATE FLUOROSURFACTANTS FOR USE IN CARBON DIOXIDE | UNIV NORTH CAROLINA (US) | 2008-07-02 | — | — | EP | disclosed |
| US-7128976-B2 | Composition for film formation, method of film formation, and silica-based film | JSR CORPORATION (JP) | 2006-10-31 | — | — | US | disclosed |
| US-7122060-B2 | Phosphate fluorosurfactants for use in carbon dioxide | THE UNIVERSITY OF NORTH CAROLINA (US) | 2006-10-17 | — | — | US | disclosed |
| EP-1328610-A4 | PHOSPHATE FLUOROSURFACTANTS FOR USE IN CARBON DIOXIDE | UNIV NORTH CAROLINA STATE (US) | 2004-09-01 | — | — | EP | disclosed |
| US-20040138080-A1 | Phosphate fluorosurfactants for use in carbon dioxide | DESIMONE JOSEPH M (US) | 2004-07-15 | — | — | US | disclosed |
| US-6684525-B2 | SURFACTANTS CONTAINING PHOSPHATE GROUP ATTACHED TO FLUOROHYDROCARABON, OR HYBRID WITH PHOSPHATE GROUP ATTACHED TO HYDROCARBON EXHIBIT SOLUBILITY IN CARBON DIOXIDE | UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL | 2004-02-03 | — | — | US | disclosed |
| EP-1328610-A1 | PHOSPHATE FLUOROSURFACTANTS FOR USE IN CARBON DIOXIDE | UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2003-07-23 | — | — | EP | disclosed |
| US-20030091838-A1 | Composition for film formation, method of film formation, and silica-based film | JSR CORPORATION (JP) | 2003-05-15 | — | — | US | disclosed |
| US-20020107159-A1 | Phosphate fluorosurfactants for use in carbon dioxide | NORTH CAROLINA STATE UNIVERSITY | 2002-08-08 | — | — | US | disclosed |
| WO-2002026921-A1 | PHOSPHATE FLUOROSURFACTANTS FOR USE IN CARBON DIOXIDE | UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2002-04-04 | — | — | WO | disclosed |