Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Piperazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | PDE4A | P27815 | 1/20 | 0.50 |
| ▸ | KDR | P35968 | 1/20 | 0.50 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 3/20 | 0.32 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.32 |
| ▸ | RGS12 | O14924 | 1/20 | 0.32 |
| ▸ | GABRR1 | P24046 | 1/20 | 0.32 |
| ▸ | GABRR2 | P28476 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | BLM | P54132 | 1/20 | 0.32 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.32 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Piperazine SCHEMBL5053500 | 1.00 | HIF1A (0.50) | HIF1AMAPTPDE4AKDRCXCR4 | |
| Piperazine SCHEMBL28128235 | 1.00 | HIF1A (0.50) | HIF1AMAPTPDE4AKDRCXCR4 | |
| Piperazine SCHEMBL27815540 | 1.00 | HIF1A (0.50) | HIF1AMAPTPDE4AKDRCXCR4 | |
| Piperazine SCHEMBL27826049 | 1.00 | HIF1A (0.50) | HIF1AMAPTPDE4AKDRCXCR4 | |
| Piperazine SCHEMBL227947 | 1.00 | HIF1A (0.50) | HIF1AMAPTPDE4AKDRCXCR4 | |
| Piperazine SCHEMBL23235242 | 1.00 | HIF1A (0.50) | HIF1AMAPTPDE4AKDRCXCR4 | |
| Piperazine SCHEMBL1972873 | 0.96 | HIF1A (0.46) | HIF1AMAPTPDE4AKDRCXCR4 | |
| Piperazine SCHEMBL15364207 | 0.96 | HIF1A (0.46) | HIF1AMAPTPDE4AKDRCXCR4 | |
| Piperazine SCHEMBL15363813 | 0.96 | HIF1A (0.46) | HIF1AMAPTPDE4AKDRCXCR4 | |
| Piperazine SCHEMBL28092756 | 0.96 | HIF1A (0.46) | HIF1AMAPTPDE4AKDRCXCR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 291 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-122079930-A | Preparation method of piperazine diphosphate metal salt flame retardant | — | 2026-05-26 | — | — | CN | claimed |
| US-20250230286-A1 | CHEMICALLY END-CAPPED POLYPIPERAZINE PYROPHOSPHATE-MODIFIED AMMONIUM POLYPHOSPHATE WITH HIGH TEMPERATURE RESISTANCE AND PRECIPITATION RESISTANCE, PREPARATION METHOD THEREFOR, AND APPARATUS AND APPLICATION THEREOF | Chongqing Copolyforce New Materials Co.,Ltd. (CN) | 2025-07-17 | — | — | US | claimed |
| CN-120192590-A | Migration-resistant piperazine pyrophosphate flame retardant and synthesis method thereof | 四川精事达科技有限公司 | 2025-06-24 | — | — | CN | claimed |
| CN-119874774-A | N, P, B integrated flame retardant and synthetic method and application thereof | 四川兴晶铧科技有限公司 | 2025-04-25 | — | — | CN | claimed |
| CN-115385869-B | High-whiteness piperazine pyrophosphate and preparation method and application thereof | 金发科技股份有限公司 | 2025-03-18 | — | — | CN | claimed |
| CN-119431947-A | Flame-retardant reinforced polypropylene composite material containing flame-retardant modified glass fiber and preparation method thereof | 重庆科聚孚新材料有限责任公司 | 2025-02-14 | — | — | CN | claimed |
| CN-116410473-B | Polymeric flame retardant and preparation method and application thereof | 清远市普塞呋磷化学有限公司 | 2025-01-17 | — | — | CN | claimed |
| CN-119241092-A | Flame-retardant modified glass fiber, preparation method thereof and application of flame-retardant reinforced polyamide | 重庆科聚孚新材料有限责任公司 | 2025-01-03 | — | — | CN | claimed |
| CN-119019693-A | Piperazine phosphate-ammonium phosphate copolymerized flame retardant, and preparation method and application thereof | 重庆科聚孚新材料有限责任公司 | 2024-11-26 | — | — | CN | claimed |
| CN-118996859-A | Flame-retardant modified carbon fiber, preparation method thereof and application of flame-retardant reinforced polypropylene | 重庆科聚孚新材料有限责任公司 | 2024-11-22 | — | — | CN | claimed |
| US-20130296467-A1 | FLAME-RETARDANT POLYOLEFIN RESIN CONTAINING PIPERAZINE-BASED METAL SALT BLEND | LOTTE CHEMICAL CORPORATION (KR) | 2013-11-07 | — | — | US | claimed |
| EP-1674459-B1 | HIGH-PURITY PIPERAZINE PYROPHOSPHATE AND METHOD FOR PRODUCING SAME | ADEKA CORP (JP) | 2012-11-14 | — | — | EP | claimed |
| CN-101955472-B | Preparation method of cinepazide maleate | YING WANG | 2012-11-14 | — | — | CN | claimed |
| US-20120190779-A1 | (POLY) PIPERAZINE PYROPHOSPHATE POWDER AND MANUFACTURING METHOD THEREFOR | SAKAI CHEMICAL INDUSTRY CO., LTD. (JP) | 2012-07-26 | — | — | US | claimed |
| EP-2468738-A1 | (POLY) PIPERAZINE PYROPHOSPHATE POWDER AND MANUFACTURING METHOD THEREFOR | SAKAI CHEMICAL INDUSTRY CO., LTD. (JP) | 2012-06-27 | — | — | EP | claimed |
| CN-100436433-C | High-purity piperazine pyrophosphate and method for producing same | ASAHI DENKA CO LTD (JP) | 2008-11-26 | — | — | CN | claimed |
| US-7449577-B2 | High purity piperazine pyrophosphate and process of producing same | ADEKA CORPORATION (JP) | 2008-11-11 | — | — | US | claimed |
| CN-1845913-A | High-purity piperazine pyrophosphate and method for producing same | ASAHI DENKA CO LTD (JP) | 2006-10-11 | — | — | CN | claimed |
| US-20060167256-A1 | High purity piperazine pyrophosphate and process of producing same | ADEKA CORPORATION (JP) | 2006-07-27 | — | — | US | claimed |
| EP-1674459-A1 | HIGH-PURITY PIPERAZINE PYROPHOSPHATE AND METHOD FOR PRODUCING SAME | Asahi Denka Co., Ltd. (JP) | 2006-06-28 | — | — | EP | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060167256-A1 | High purity piperazine pyrophosphate and process of producing same | DCTPP1, DHPS, PPA1 | HIF1A 1978/4885MAPT 2264/4885PDE4A 1538/4885 |
| US-20120190779-A1 | (POLY) PIPERAZINE PYROPHOSPHATE POWDER AND MANUFACTURING METHOD THEREFOR | PPIP5K2, GGPS1, ITPA | HIF1A 1620/4885MAPT 2143/4885PDE4A 2683/4885 |
| US-20250230286-A1 | CHEMICALLY END-CAPPED POLYPIPERAZINE PYROPHOSPHATE-MODIFIED AMMONIUM POLYPHOSPHATE WITH HIGH TEMPERATURE RESISTANCE AND PRECIPITATION RESISTANCE, PREPARATION METHOD THEREFOR, AND APPARATUS AND APPLICATION THEREOF | PPA1, DCTPP1, AGPS | HIF1A 3959/4885MAPT 1847/4885PDE4A 4003/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.