Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.36 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.36 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.36 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.36 |
| ▸ | CHRNA6 | Q15825 | 1/20 | 0.36 |
| ▸ | GNAI3 | P08754 | 7/20 | 0.35 |
| ▸ | GNAO1 | P09471 | 7/20 | 0.35 |
| ▸ | GNAI1 | P63096 | 7/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | PREP | P48147 | 2/20 | 0.33 |
| ▸ | FOS | P01100 | 1/20 | 0.33 |
| ▸ | JUN | P05412 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25123575 | 0.88 | NPC1 (0.38) | MEN1KMT2APOLBMAPTNPC1 | |
| SCHEMBL25914467 | 0.88 | NPC1 (0.38) | MEN1KMT2APOLBMAPTNPC1 | |
| SCHEMBL25877388 | 0.88 | NPC1 (0.38) | MEN1KMT2APOLBMAPTNPC1 | |
| SCHEMBL23696466 | 0.88 | NPC1 (0.38) | MEN1KMT2APOLBMAPTNPC1 | |
| SCHEMBL22856170 | 0.85 | MEN1 (0.51) | MEN1KMT2APOLBMAPTNPC1 | |
| SCHEMBL24508295 | 0.82 | NPC1 (0.34) | MEN1KMT2APOLBMAPTNPC1 | |
| SCHEMBL24511299 | 0.82 | FAAH (0.35) | MEN1KMT2APOLBMAPTNPC1 | |
| SCHEMBL23945313 | 0.81 | GNAI3 (0.40) | MEN1KMT2APOLBMAPTGNAI3 | |
| SCHEMBL23806469 | 0.80 | MEN1 (0.47) | MEN1KMT2APOLBMAPTNPC1 | |
| SCHEMBL24508742 | 0.80 | MEN1 (0.47) | MEN1KMT2APOLBMAPTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020251971-A1 | SMARCA DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2020-12-17 | — | — | WO | disclosed |