SCHEMBL22795309

SCHEMBL22795309

Cc1cc2cccc3cc(N)c4cccc1c4c23

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TDP1 Q9NUW8 3/20 0.44
KDM4E B2RXH2 3/20 0.44
ALDH1A1 P00352 7/20 0.44
HPGD P15428 6/20 0.44
HSD17B10 Q99714 5/20 0.44
CYP3A4 P08684 3/20 0.44
TSHR P16473 3/20 0.44
L3MBTL1 Q9Y468 1/20 0.44
PKM P14618 1/20 0.40
CYP1A2 P05177 4/20 0.39
CYP2A6 P11509 3/20 0.39
BACE1 P56817 1/20 0.39
NCF1 P14598 1/20 0.39
KEAP1 Q14145 2/20 0.39
NR4A2 P43354 1/20 0.39
CCR1 P32246 1/20 0.38
CCR8 P51685 1/20 0.38
ERBB2 P04626 1/20 0.37
FYN P06241 1/20 0.37
MAOA P21397 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24041353 0.94 TDP1 (0.46) TDP1KDM4EALDH1A1HPGDHSD17B10
SCHEMBL5745730 0.85 ALDH1A1 (0.55) TDP1KDM4EALDH1A1HPGDHSD17B10
SCHEMBL5746036 0.85 ALDH1A1 (0.59) TDP1KDM4EALDH1A1HPGDHSD17B10
SCHEMBL5748513 0.81 ALDH1A1 (0.55) TDP1KDM4EALDH1A1HPGDHSD17B10
SCHEMBL9058600 0.81 ALDH1A1 (0.50) TDP1KDM4EALDH1A1HPGDHSD17B10
SCHEMBL31162741 0.79 ALDH1A1 (0.68) TDP1KDM4EALDH1A1HPGDHSD17B10
SCHEMBL15327722 0.79 ALDH1A1 (0.68) TDP1KDM4EALDH1A1HPGDHSD17B10
SCHEMBL31298002 0.79 CYP1A2 (0.57) TDP1KDM4EALDH1A1HPGDHSD17B10
SCHEMBL1899794 0.79 CYP1A2 (0.57) TDP1KDM4EALDH1A1HPGDHSD17B10
SCHEMBL5747475 0.78 ALDH1A1 (0.55) TDP1KDM4EALDH1A1HPGDHSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2020251049-A1 POLYCYCLIC AROMATIC COMPOUND 学校法人関西学院 2020-12-17 WO disclosed