Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | KDM1A | O60341 | 2/20 | 0.41 |
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.39 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 3/20 | 0.39 |
| ▸ | JAK1 | P23458 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL651769 | 1.00 | ATM (0.46) | ATMGPR119TSHRALOX15KDM4E | |
| SCHEMBL651751 | 1.00 | ATM (0.46) | ATMGPR119TSHRALOX15KDM4E | |
| SCHEMBL28331122 | 0.84 | GPR119 (0.47) | ATMGPR119KDM4EPKMKDM1A | |
| SCHEMBL28331123 | 0.84 | GPR119 (0.47) | ATMGPR119KDM4EPKMKDM1A | |
| SCHEMBL22147785 | 0.77 | GPR119 (0.48) | ATMGPR119TSHRALOX15KDM4E | |
| SCHEMBL25465736 | 0.75 | KDM4E (0.47) | ATMGPR119TSHRALOX15KDM4E | |
| SCHEMBL12683487 | 0.75 | GPR119 (0.53) | GPR119KDM4EPKMUSP30ACKR3 | |
| SCHEMBL12683573 | 0.75 | GPR119 (0.53) | GPR119KDM4EPKMUSP30ACKR3 | |
| SCHEMBL16459716 | 0.75 | GPR119 (0.53) | GPR119KDM4EPKMUSP30ACKR3 | |
| SCHEMBL28520003 | 0.75 | GPR119 (0.53) | GPR119KDM4EPKMUSP30ACKR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3753934-A1 | PYRIMIDINYL DERIVATIVES USEFUL AS TYROSINE KINASE INHIBITORS | Biogen MA Inc. (US) | 2020-12-23 | — | — | EP | disclosed |