Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.41 |
| ▸ | SYNJ2 | O15056 | 3/20 | 0.40 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.40 |
| ▸ | CHRNA5 | P30532 | 1/20 | 0.40 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.40 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24672888 | 0.85 | KMT2A (0.43) | NPC1ALDH1A1SLC22A1CHRNB2CHRNA5 | |
| SCHEMBL22799538 | 0.85 | KMT2A (0.43) | NPC1ALDH1A1SLC22A1CHRNB2CHRNA5 | |
| SCHEMBL24672884 | 0.85 | KMT2A (0.43) | NPC1ALDH1A1SLC22A1CHRNB2CHRNA5 | |
| SCHEMBL22797460 | 0.81 | ALDH1A1 (0.50) | NPC1ALDH1A1SLC22A1SYNJ2CHRNB2 | |
| SCHEMBL24673842 | 0.81 | ALDH1A1 (0.50) | NPC1ALDH1A1SLC22A1SYNJ2CHRNB2 | |
| SCHEMBL22799532 | 0.81 | ALDH1A1 (0.50) | NPC1ALDH1A1SLC22A1SYNJ2CHRNB2 | |
| SCHEMBL24673043 | 0.81 | ALDH1A1 (0.50) | NPC1ALDH1A1SLC22A1SYNJ2CHRNB2 | |
| SCHEMBL22799526 | 0.81 | ALDH1A1 (0.50) | NPC1ALDH1A1SLC22A1SYNJ2CHRNB2 | |
| SCHEMBL22797461 | 0.81 | ALDH1A1 (0.50) | NPC1ALDH1A1SLC22A1SYNJ2CHRNB2 | |
| SCHEMBL22799502 | 0.80 | ABCB1 (0.41) | NPC1ALDH1A1POLBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220275018-A1 | NOVEL SPIROBICYCLIC INTERMEDIATES | JANSSEN PHARMACEUTICA NV (BE) | 2022-09-01 | — | — | US | disclosed |
| WO-2020249663-A1 | NOVEL SPIROBICYCLIC INTERMEDIATES | JANSSEN PHARMACEUTICA NV (BE) | 2020-12-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220275018-A1 | NOVEL SPIROBICYCLIC INTERMEDIATES | NME2, SLC28A1, SLC28A2 | NPC1 398/4885ALDH1A1 248/4885SLC22A1 405/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.