Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | CFTR | P13569 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22800173 | 0.97 | ALDH1A1 (0.46) | ALDH1A1LMNACYP3A4KDM4EL3MBTL1 | |
| SCHEMBL22799659 | 0.95 | ALDH1A1 (0.48) | ALDH1A1LMNACYP3A4KDM4EKMT2A | |
| SCHEMBL22799781 | 0.90 | ALDH1A1 (0.51) | ALDH1A1LMNACYP3A4KDM4EKMT2A | |
| SCHEMBL22800187 | 0.88 | ALDH1A1 (0.47) | ALDH1A1LMNACYP3A4KDM4EKMT2A | |
| SCHEMBL22799629 | 0.85 | L3MBTL1 (0.46) | ALDH1A1CYP3A4L3MBTL1KMT2ATSHR | |
| SCHEMBL22800168 | 0.83 | L3MBTL1 (0.47) | ALDH1A1CYP3A4L3MBTL1KMT2ATSHR | |
| SCHEMBL22800222 | 0.80 | ALDH1A1 (0.47) | ALDH1A1LMNAKDM4EKMT2ACYP1A2 | |
| SCHEMBL12291117 | 0.80 | ALDH1A1 (0.47) | ALDH1A1LMNAKDM4EKMT2ACYP1A2 | |
| SCHEMBL6669086 | 0.80 | ALDH1A1 (0.62) | ALDH1A1LMNAKDM4EKMT2ATSHR | |
| SCHEMBL22799660 | 0.79 | CYP3A4 (0.46) | ALDH1A1CYP3A4L3MBTL1KMT2ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200392157-A1 | CALPAIN MODULATORS AND THERAPEUTIC USES THEREOF | Knobbe, Martens, Olson & Bear, LLP | 2020-12-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200392157-A1 | CALPAIN MODULATORS AND THERAPEUTIC USES THEREOF | CAPNS1, CAPN2, CAPN1 | ALDH1A1 3918/4885LMNA 1070/4885CYP3A4 4538/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.