Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | CTSK | P43235 | 1/20 | 0.48 |
| ▸ | CAPN1 | P07384 | 6/20 | 0.47 |
| ▸ | GALR1 | P47211 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | FAAH | O00519 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22800154 | 0.77 | ALDH1A1 (0.46) | ALDH1A1GALR1NPSR1LMNATP53 | |
| SCHEMBL22799838 | 0.76 | ALDH1A1 (0.51) | ALDH1A1CAPN1GALR1NPSR1LMNA | |
| SCHEMBL12983793 | 0.73 | ALDH1A1 (0.55) | ALDH1A1GALR1NPSR1LMNATP53 | |
| SCHEMBL22801013 | 0.73 | MAPT (0.40) | CTSKCAPN1TSHRMAPTTHRB | |
| SCHEMBL2327662 | 0.70 | ALDH1A1 (0.54) | ALDH1A1GALR1NPSR1LMNATP53 | |
| SCHEMBL2327655 | 0.70 | ALDH1A1 (0.54) | ALDH1A1GALR1NPSR1LMNATP53 | |
| SCHEMBL22800170 | 0.69 | KDM4E (0.43) | ALDH1A1NPSR1LMNATP53HPGD | |
| SCHEMBL2324537 | 0.69 | ALDH1A1 (0.53) | ALDH1A1GALR1NPSR1LMNATP53 | |
| SCHEMBL2326789 | 0.69 | RAB9A (0.53) | ALDH1A1NPSR1TP53KMT2A | |
| SCHEMBL2326786 | 0.69 | RAB9A (0.53) | ALDH1A1NPSR1TP53KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200392157-A1 | CALPAIN MODULATORS AND THERAPEUTIC USES THEREOF | Knobbe, Martens, Olson & Bear, LLP | 2020-12-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200392157-A1 | CALPAIN MODULATORS AND THERAPEUTIC USES THEREOF | CAPNS1, CAPN2, CAPN1 | ALDH1A1 3918/4885CTSK 118/4885CAPN1 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.