Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 5/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22900030 | 0.79 | ALDH1A1 (0.57) | POLBALDH1A1 | |
| SCHEMBL15490022 | 0.77 | POLB (0.46) | POLBNPSR1L3MBTL1SMN1; SMN2ATM | |
| SCHEMBL25498527 | 0.75 | DPP4 (0.39) | ALDH1A1 | |
| SCHEMBL12384369 | 0.75 | POLB (0.47) | POLBNPSR1L3MBTL1SMN1; SMN2ATM | |
| SCHEMBL674328 | 0.74 | — | — | |
| SCHEMBL22434895 | 0.74 | POLB (0.70) | POLBNPSR1L3MBTL1SMN1; SMN2ATM | |
| SCHEMBL18199496 | 0.74 | POLB (0.70) | POLBNPSR1L3MBTL1SMN1; SMN2ATM | |
| SCHEMBL22900008 | 0.73 | POLB (0.42) | POLBNPSR1L3MBTL1SMN1; SMN2ATM | |
| SCHEMBL24597150 | 0.72 | SMN1; SMN2 (0.48) | SMN1; SMN2ALDH1A1KMT2AMEN1KDM4E | |
| SCHEMBL21112193 | 0.72 | VNN1 (0.38) | SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020249792-A1 | SUBSTITUTED PYRAZOLO-PYRIDINE AMIDES AND THEIR USE AS GLUN2B RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2020-12-17 | — | — | WO | disclosed |