Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K4 | P45985 | 13/20 | 1.00 |
| ▸ | MAPK1 | P28482 | 6/20 | 0.70 |
| ▸ | MAPK6 | Q16659 | 6/20 | 0.70 |
| ▸ | MAPKAPK5 | Q8IW41 | 2/20 | 0.65 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.61 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.61 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.61 |
| ▸ | MAPKAPK3 | Q16644 | 4/20 | 0.58 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.50 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.50 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.49 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.49 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.49 |
| ▸ | CDH1 | P12830 | 1/20 | 0.48 |
| ▸ | APC | P25054 | 1/20 | 0.48 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.48 |
| ▸ | TCF7L2 | Q9NQB0 | 1/20 | 0.48 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.47 |
| ▸ | GSK3B | P49841 | 1/20 | 0.47 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22801611 | 0.83 | MAP2K4 (1.00) | MAP2K4MAPK1MAPK6MAPKAPK5MAPK8 | |
| SCHEMBL22819377 | 0.82 | MAP2K4 (1.00) | MAP2K4MAPK1MAPK6MAPKAPK5MAPK8 | |
| SCHEMBL4032441 | 0.81 | PDPK1 (0.75) | MAP2K4MAPK1MAPK6MAPKAPK5MAPKAPK3 | |
| SCHEMBL144764 | 0.79 | MAP2K4 (0.65) | MAP2K4MAPK1MAPK6MAPKAPK5 | |
| SCHEMBL23206693 | 0.79 | MAP2K4 (0.65) | MAP2K4MAPK1MAPK6MAPKAPK5MAPK8 | |
| SCHEMBL22801763 | 0.79 | MAP2K4 (1.00) | MAP2K4MAPK1MAPK6MAPKAPK5MAPK8 | |
| SCHEMBL14738828 | 0.79 | MAP2K4 (0.63) | MAP2K4MAPK8MAPK10MAPK14PDPK1 | |
| SCHEMBL3732433 | 0.78 | MAP2K4 (1.00) | MAP2K4MAPK1MAPK6MAPKAPK5MAPK8 | |
| SCHEMBL9271850 | 0.78 | MAP2K4 (0.64) | MAP2K4MAPK1MAPK6MAPKAPK3PDPK1 | |
| SCHEMBL22819380 | 0.78 | MAP2K4 (0.63) | MAP2K4MAPK1MAPK6MAPKAPK5MAPK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11370770-B2 | 3-arylindazoles as selective MEK4 inhibitors | NORTHWESTERN UNIVERSITY (US) | 2022-06-28 | — | — | US | disclosed |
| US-11370770-B2 | 3-arylindazoles as selective MEK4 inhibitors | NORTHWESTERN UNIVERSITY (US) | 2022-06-28 | — | — | US | disclosed |
| US-20200399241-A1 | 3-ARYLINDAZOLES AS SELECTIVE MEK4 INHIBITORS | NORTHWESTERN UNIVERSITY (US) | 2020-12-24 | — | — | US | disclosed |
| US-20200399241-A1 | 3-ARYLINDAZOLES AS SELECTIVE MEK4 INHIBITORS | NORTHWESTERN UNIVERSITY (US) | 2020-12-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200399241-A1 | 3-ARYLINDAZOLES AS SELECTIVE MEK4 INHIBITORS | MAP4K3, MAPK4, MAP3K4 | MAP2K4 39/4885MAPK1 32/4885MAPK6 42/4885 |
| US-11370770-B2 | 3-arylindazoles as selective MEK4 inhibitors | MAP4K3, MAPK4, MAP3K4 | MAP2K4 39/4885MAPK1 32/4885MAPK6 42/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.