Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K4 | P45985 | 8/20 | 1.00 |
| ▸ | MAPK1 | P28482 | 6/20 | 0.70 |
| ▸ | MAPK6 | Q16659 | 5/20 | 0.70 |
| ▸ | MAPKAPK3 | Q16644 | 3/20 | 0.70 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.68 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.68 |
| ▸ | IDO1 | P14902 | 2/20 | 0.68 |
| ▸ | ALPL | P05186 | 1/20 | 0.68 |
| ▸ | GAA | P10253 | 1/20 | 0.68 |
| ▸ | HPGD | P15428 | 1/20 | 0.68 |
| ▸ | TTK | P33981 | 1/20 | 0.68 |
| ▸ | ITK | Q08881 | 1/20 | 0.60 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.60 |
| ▸ | MAPKAPK5 | Q8IW41 | 1/20 | 0.59 |
| ▸ | NPC1 | O15118 | 1/20 | 0.58 |
| ▸ | TP53 | P04637 | 1/20 | 0.58 |
| ▸ | RAB9A | P51151 | 1/20 | 0.58 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.56 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22801827 | 0.83 | MAP2K4 (1.00) | MAP2K4MAPK1MAPK6MAPKAPK3KDM4E | |
| SCHEMBL22044452 | 0.82 | MAP2K4 (0.69) | MAP2K4MAPK1MAPK6MAPKAPK3KDM4E | |
| SCHEMBL17178615 | 0.82 | ALDH1A1 (0.92) | MAP2K4MAPK1MAPK6MAPKAPK3KDM4E | |
| SCHEMBL2866791 | 0.82 | MAP2K4 (0.69) | MAP2K4MAPK1MAPK6MAPKAPK3KDM4E | |
| SCHEMBL12326463 | 0.82 | ATM (0.72) | MAP2K4MAPK1KDM4EALDH1A1GAA | |
| SCHEMBL30768403 | 0.82 | ALDH1A1 (1.00) | MAP2K4MAPK1MAPK6MAPKAPK3KDM4E | |
| SCHEMBL855531 | 0.82 | ALDH1A1 (1.00) | MAP2K4MAPK1MAPK6MAPKAPK3KDM4E | |
| SCHEMBL5769397 | 0.82 | MAP2K4 (0.67) | MAP2K4MAPK1MAPK6MAPKAPK3KDM4E | |
| SCHEMBL8126956 | 0.81 | MAPK1 (0.72) | MAP2K4MAPK1MAPK6MAPKAPK3KDM4E | |
| SCHEMBL13503119 | 0.80 | MAP2K4 (0.67) | MAP2K4MAPK1MAPK6MAPKAPK3KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250179046-A1 | SEROTONIN 5-HT2B INHIBITORY COMPOUNDS | ZOETIS SERVICES LLC | 2025-06-05 | — | — | US | disclosed |
| US-12240827-B2 | Serotonin 5-HT2B inhibitory compounds | ZOETIS SERVICES LLC (US) | 2025-03-04 | — | — | US | disclosed |
| EP-3947360-B1 | SEROTONIN 5-HT2B INHIBITORY COMPOUNDS | ZOETIS SERVICES LLC (US) | 2024-08-07 | — | — | EP | disclosed |
| CN-113631548-B | Serotonin 5-HT2B inhibiting compounds | 硕腾服务有限责任公司 | 2023-06-06 | — | — | CN | disclosed |
| US-20220162183-A1 | SEROTONIN 5-HT2B INHIBITORY COMPOUNDS | ZOETIS SERVICES LLC | 2022-05-26 | — | — | US | disclosed |
| EP-3947360-A1 | SEROTONIN 5-HT2B INHIBITORY COMPOUNDS | Zoetis Services LLC (US) | 2022-02-09 | — | — | EP | disclosed |
| CN-113631548-A | Serotonin 5-HT2B inhibiting compounds | 硕腾服务有限责任公司 | 2021-11-09 | — | — | CN | disclosed |
| WO-2020198478-A1 | SEROTONIN 5-HT2B INHIBITORY COMPOUNDS | ZOETIS SERVICES LLC (US) | 2020-10-01 | — | — | WO | disclosed |
| US-9850276-B2 | Bidentate-binding modulators of LRRK2 and JNK kinases | THE SCRIPPS RESEARCH INSTITUTE (US) | 2017-12-26 | — | — | US | disclosed |
| US-9850276-B2 | Bidentate-binding modulators of LRRK2 and JNK kinases | THE SCRIPPS RESEARCH INSTITUTE (US) | 2017-12-26 | — | — | US | disclosed |
| US-20160185818-A1 | BIDENTATE-BINDING MODULATORS OF LRRK2 AND JNK KINASES | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED | 2016-06-30 | — | — | US | disclosed |
| EP-3003302-A1 | BIDENTATE-BINDING MODULATORS OF LRRK2 AND JNK KINASES | The Scripps Research Institute (US) | 2016-04-13 | — | — | EP | disclosed |
| WO-2014200682-A1 | BIDENTATE-BINDING MODULATORS OF LRRK2 AND JNK KINASES | THE SCRIPPS RESEARCH INSTITUTE (US) | 2014-12-18 | — | — | WO | disclosed |
| WO-2014200682-A1 | BIDENTATE-BINDING MODULATORS OF LRRK2 AND JNK KINASES | THE SCRIPPS RESEARCH INSTITUTE (US) | 2014-12-18 | — | — | WO | disclosed |
| US-20110212961-A1 | Pyrazole Derivatives as Kinase Inhibitors | BURNHAM INSTITUTE FOR MEDICAL RESEARCH | 2011-09-01 | — | — | US | disclosed |
| US-7951832-B2 | Pyrazole derivatives as kinase inhibitors | BURNHAM INSTITUTE FOR MEDICAL RESEARCH (US) | 2011-05-31 | — | — | US | disclosed |
| EP-2155719-A1 | AZACYCLYLBENZAMIDE DERIVATIVES AS HISTAMINE-3 ANTAGONISTS | Wyeth LLC (US) | 2010-02-24 | — | — | EP | disclosed |
| US-20090124621-A1 | PYRAZOLE DERIVATIVES AS KINASE INHIBITORS | BURNHAM INSTITUTE FOR MEDICAL RESEARCH (US) | 2009-05-14 | — | — | US | disclosed |
| WO-2009018490-A1 | BI-DENTATE COMPOUNDS AS KINASE INHIBITORS | BURNHAM INSTITUTE FOR MEDICAL RESEARCH (US) | 2009-02-05 | — | — | WO | disclosed |
| WO-2008147945-A1 | AZACYCLYLBENZAMIDE DERIVATIVES AS HISTAMINE-3 ANTAGONISTS | WYETH (US) | 2008-12-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12240827-B2 | Serotonin 5-HT2B inhibitory compounds | HTR2B, HTR1B, HTR5A | MAP2K4 2790/4885MAPK1 2858/4885MAPK6 3413/4885 |
| US-20220162183-A1 | SEROTONIN 5-HT2B INHIBITORY COMPOUNDS | HTR2B, HTR1B, HTR5A | MAP2K4 2790/4885MAPK1 2858/4885MAPK6 3413/4885 |
| US-20250179046-A1 | SEROTONIN 5-HT2B INHIBITORY COMPOUNDS | HTR2B, HTR1B, HTR5A | MAP2K4 2790/4885MAPK1 2858/4885MAPK6 3413/4885 |
| US-20160185818-A1 | BIDENTATE-BINDING MODULATORS OF LRRK2 AND JNK KINASES | LRRK2, PINK1, MAP2K3 | MAP2K4 12/4885MAPK1 144/4885MAPK6 122/4885 |
| US-20090124621-A1 | PYRAZOLE DERIVATIVES AS KINASE INHIBITORS | BRAF, MAP3K1, MAP3K3 | MAP2K4 225/4885MAPK1 81/4885MAPK6 82/4885 |
| US-20110212961-A1 | Pyrazole Derivatives as Kinase Inhibitors | BRAF, MAP3K1, MAP3K3 | MAP2K4 225/4885MAPK1 81/4885MAPK6 82/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.