Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K4 | P45985 | 4/20 | 0.63 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.49 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.48 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.48 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.47 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.47 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.47 |
| ▸ | GSK3B | P49841 | 2/20 | 0.46 |
| ▸ | ESR1 | P03372 | 1/20 | 0.46 |
| ▸ | IDO1 | P14902 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | DAO | P14920 | 1/20 | 0.44 |
| ▸ | NOS1 | P29475 | 1/20 | 0.44 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.44 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.43 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4032441 | 0.84 | PDPK1 (0.75) | MAP2K4PDPK1HSP90AB1FGFR1FGFR2 | |
| SCHEMBL9271850 | 0.84 | MAP2K4 (0.64) | MAP2K4TRPA1PDPK1HSP90AB1FGFR1 | |
| SCHEMBL3593032 | 0.83 | MAP2K4 (0.50) | MAP2K4TRPA1GSK3BDAONOS1 | |
| SCHEMBL4032487 | 0.81 | MAP2K4 (0.61) | MAP2K4TRPA1PDPK1HSP90AB1FGFR1 | |
| SCHEMBL4502873 | 0.81 | PDPK1 (0.60) | MAP2K4TRPA1PDPK1GSK3BCHEK1 | |
| SCHEMBL22819380 | 0.80 | MAP2K4 (0.63) | MAP2K4TRPA1PDPK1HSP90AB1FGFR1 | |
| SCHEMBL1553907 | 0.79 | MAP2K4 (0.47) | MAP2K4TRPA1GSK3BDAONOS1 | |
| SCHEMBL15529807 | 0.79 | GSK3B (0.48) | MAP2K4TRPA1PDPK1GSK3BDAO | |
| SCHEMBL2955244 | 0.79 | MAP2K4 (0.55) | MAP2K4TRPA1PDPK1HSP90AB1FGFR1 | |
| SCHEMBL3155790 | 0.79 | CHEK1 (0.50) | MAP2K4TRPA1GSK3BDAONOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2763990-B1 | PYRROLOPYRAZINE KINASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2017-02-22 | — | — | EP | disclosed |
| US-8658646-B2 | Pyrrolopyrazine kinase inhibitors | HOFFMANN-LAROCHE INC. (US) | 2014-02-25 | — | — | US | disclosed |
| US-20130059834-A1 | PYRROLOPYRAZINE KINASE INHIBITORS | HOFFMANN-LA ROCHE INC. | 2013-03-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130059834-A1 | PYRROLOPYRAZINE KINASE INHIBITORS | SYK, ZAP70, JAK1 | MAP2K4 772/4885TRPA1 4079/4885PDPK1 98/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.