Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | KDR | P35968 | 13/20 | 0.47 |
| ▸ | PRKAA1 | Q13131 | 10/20 | 0.47 |
| ▸ | PRKAA2 | P54646 | 8/20 | 0.47 |
| ▸ | PDGFRB | P09619 | 7/20 | 0.47 |
| ▸ | FGFR1 | P11362 | 5/20 | 0.47 |
| ▸ | EGFR | P00533 | 6/20 | 0.45 |
| ▸ | CSF1R | P07333 | 3/20 | 0.45 |
| ▸ | FLT3 | P36888 | 3/20 | 0.45 |
| ▸ | KIT | P10721 | 3/20 | 0.45 |
| ▸ | PLK4 | O00444 | 2/20 | 0.45 |
| ▸ | DCLK1 | O15075 | 2/20 | 0.45 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.45 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.45 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.45 |
| ▸ | RPS6KA5 | O75582 | 2/20 | 0.45 |
| ▸ | RPS6KA4 | O75676 | 2/20 | 0.45 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.45 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.45 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19442393 | 0.84 | ALDH1A1 (0.55) | ALDH1A1KDRPRKAA1PRKAA2PDGFRB | |
| SCHEMBL24336951 | 0.81 | ALDH1A1 (0.52) | ALDH1A1KDRPRKAA1PRKAA2PDGFRB | |
| SCHEMBL15132782 | 0.80 | ALDH1A1 (0.67) | ALDH1A1KDRPRKAA1PRKAA2PDGFRB | |
| SCHEMBL1044420 | 0.80 | KDR (0.59) | ALDH1A1KDRPRKAA1PRKAA2PDGFRB | |
| SCHEMBL2730804 | 0.79 | ALDH1A1 (0.54) | ALDH1A1KDRPRKAA1PRKAA2PDGFRB | |
| SCHEMBL21916086 | 0.78 | ALDH1A1 (0.50) | ALDH1A1KDRPRKAA1PRKAA2PDGFRB | |
| SCHEMBL12118142 | 0.78 | KDR (0.50) | ALDH1A1KDRPRKAA1PRKAA2PDGFRB | |
| SCHEMBL24336612 | 0.77 | ALDH1A1 (0.49) | ALDH1A1KDRPRKAA1PRKAA2PDGFRB | |
| SCHEMBL15132781 | 0.75 | KDR (0.55) | KDRPRKAA1PRKAA2PDGFRBFGFR1 | |
| SCHEMBL12281600 | 0.74 | ALDH1A1 (0.46) | ALDH1A1KDRPRKAA1PRKAA2PDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12037342-B2 | Substituted eneoxindoles and uses thereof | GILEAD SCIENCES, INC. (US) | 2024-07-16 | — | — | US | disclosed |
| US-20230183262-A1 | SUBSTITUTED ENEOXINDOLES AND USES THEREOF | GILEAD SCIENCES, INC. | 2023-06-15 | — | — | US | disclosed |
| US-20200392153-A1 | SUBSTITUTED ENEOXINDOLES AND USES THEREOF | GILEAD SCIENCES, INC. | 2020-12-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230183262-A1 | SUBSTITUTED ENEOXINDOLES AND USES THEREOF | HIPK1, HPGDS, HIPK3 | ALDH1A1 1940/4885KDR 3759/4885PRKAA1 342/4885 |
| US-12037342-B2 | Substituted eneoxindoles and uses thereof | HIPK1, HPGDS, HIPK3 | ALDH1A1 1940/4885KDR 3759/4885PRKAA1 342/4885 |
| US-20200392153-A1 | SUBSTITUTED ENEOXINDOLES AND USES THEREOF | HIPK1, HPGDS, HIPK3 | ALDH1A1 1940/4885KDR 3759/4885PRKAA1 342/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.