SCHEMBL2280864

SCHEMBL2280864

Fc1cc(F)cc(-c2cnc(-c3ccccc3)c(-c3ccccc3)n2)c1

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TDP1 Q9NUW8 3/20 0.55
CTDSP1 Q9GZU7 1/20 0.55
CKS1B P61024 1/20 0.46
SKP1 P63208 1/20 0.46
SKP2 Q13309 1/20 0.46
BCHE P06276 1/20 0.42
ACHE P22303 1/20 0.42
RAB9A P51151 2/20 0.41
NPC1 O15118 1/20 0.41
PDGFRB P09619 1/20 0.41
KDR P35968 1/20 0.41
FLT3 P36888 1/20 0.41
SMN1; SMN2 Q16637 1/20 0.41
ADORA1 P30542 1/20 0.41
TAAR1 Q96RJ0 1/20 0.40
RXRA P19793 1/20 0.40
RXRB P28702 1/20 0.40
RXRG P48443 1/20 0.40
CNR1 P21554 1/20 0.40
KDM4E B2RXH2 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2280207 0.90 BCHE (0.54) TDP1CTDSP1CKS1BSKP1SKP2
SCHEMBL16622232 0.85 CTDSP1 (0.46) TDP1CTDSP1CKS1BSKP1SKP2
SCHEMBL87574 0.85 CKS1B (0.55) CKS1BSKP1SKP2RAB9ANPC1
SCHEMBL29406280 0.83 CKS1B (0.53) CKS1BSKP1SKP2RAB9ANPC1
SCHEMBL28243355 0.83 CKS1B (0.53) CKS1BSKP1SKP2RAB9ANPC1
SCHEMBL27816089 0.83 CKS1B (0.53) CKS1BSKP1SKP2RAB9ANPC1
SCHEMBL19820819 0.82 CKS1B (0.57) TDP1CKS1BSKP1SKP2RAB9A
SCHEMBL16750246 0.81 CKS1B (0.52) TDP1CKS1BSKP1SKP2BCHE
SCHEMBL2910144 0.78 BCHE (0.49) TDP1CTDSP1BCHEACHERAB9A
SCHEMBL2482887 0.76 NPC1 (0.56) BCHEACHERAB9ANPC1PDGFRB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7993494-B2 Method for manufacturing triarylpyrazine derivative SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2011-08-09 US disclosed
US-7993494-B2 Method for manufacturing triarylpyrazine derivative SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2011-08-09 US disclosed
US-7993494-B2 Method for manufacturing triarylpyrazine derivative SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2011-08-09 US disclosed
US-20090183982-A1 Method for Manufacturing Triarylpyrazine Derivative SEMICONDUCTOR ENERGY LABORATORY CO., LTD. 2009-07-23 US disclosed
US-20090183982-A1 Method for Manufacturing Triarylpyrazine Derivative SEMICONDUCTOR ENERGY LABORATORY CO., LTD. 2009-07-23 US disclosed
US-20090183982-A1 Method for Manufacturing Triarylpyrazine Derivative SEMICONDUCTOR ENERGY LABORATORY CO., LTD. 2009-07-23 US disclosed