Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 1/20 | 0.41 |
| ▸ | SCN9A | Q15858 | 12/20 | 0.38 |
| ▸ | HSF1 | Q00613 | 1/20 | 0.37 |
| ▸ | SCN7A | Q01118 | 4/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | PDE1A | P54750 | 1/20 | 0.34 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.34 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.34 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22809472 | 0.89 | BACE1 (0.54) | BACE1SCN9ASCN7AKCNH2SCN10A | |
| Hydrochloric Acid SCHEMBL20595231 | 0.87 | BACE1 (0.53) | BACE1SCN9ASCN7AKCNH2SCN10A | |
| SCHEMBL22809561 | 0.86 | BACE1 (0.41) | BACE1SCN9AHSF1SCN7AKCNH2 | |
| SCHEMBL22809481 | 0.74 | BACE1 (0.47) | BACE1SCN9ASCN7AKCNH2SCN10A | |
| SCHEMBL28350726 | 0.74 | BACE1 (0.47) | BACE1SCN9ASCN7AKCNH2SCN10A | |
| SCHEMBL3338851 | 0.70 | TLR8 (0.44) | SCN7AKCNH2SCN10A | |
| SCHEMBL28354796 | 0.69 | SCN9A (0.48) | SCN9ASCN7AKCNH2SCN10ASCN5A | |
| SCHEMBL19798863 | 0.66 | BACE1 (0.39) | BACE1KCNH2SCN10AMEN1KMT2A | |
| SCHEMBL2001524 | 0.66 | HPGD (0.48) | SCN9ASMN1; SMN2MAPTKMT2A | |
| SCHEMBL28563865 | 0.66 | ALDH1A1 (0.55) | SMN1; SMN2MEN1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3487839-B1 | AMIDE DERIVATIVES AS NAV1.7 AND NAV1.8 BLOCKERS | RAQUALIA PHARMA INC (JP) | 2020-12-23 | — | — | EP | disclosed |