Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.50 |
| ▸ | SCN8A | Q9UQD0 | 2/20 | 0.49 |
| ▸ | SCN10A | Q9Y5Y9 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | AR | P10275 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19524139 | 0.90 | SCN8A (0.52) | HPGDL3MBTL1SCN8ASCN10AALDH1A1 | |
| SCHEMBL27340001 | 0.87 | CYP1A2 (0.54) | HPGDL3MBTL1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL19563650 | 0.85 | ALDH1A1 (0.44) | L3MBTL1CYP1A2CYP2C9CYP2C19LMNA | |
| SCHEMBL19524164 | 0.83 | MAPT (0.65) | L3MBTL1SCN8ASCN10ACYP1A2CYP2C9 | |
| SCHEMBL22809605 | 0.82 | SCN8A (0.47) | L3MBTL1SCN8ASCN10ACYP1A2CYP2C9 | |
| SCHEMBL19563618 | 0.82 | SCN8A (0.47) | SCN8ASCN10ACYP1A2CYP2C9CYP2C19 | |
| SCHEMBL21130218 | 0.82 | SCN8A (0.50) | SCN8ASCN10ACYP1A2CYP2C9CYP2C19 | |
| SCHEMBL2174398 | 0.80 | ALDH1A1 (0.58) | HPGDL3MBTL1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL19524146 | 0.80 | KMT2A (0.49) | HPGDSCN8ASCN10ALMNAMAPT | |
| SCHEMBL957465 | 0.79 | CYP2C19 (0.50) | HPGDL3MBTL1CYP1A2CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3239134-B1 | PYRIDONE AMIDES AS MODULATORS OF SODIUM CHANNELS | VERTEX PHARMA (US) | 2020-12-23 | — | — | EP | disclosed |