Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN8A | Q9UQD0 | 7/20 | 0.50 |
| ▸ | SCN10A | Q9Y5Y9 | 7/20 | 0.50 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19563650 | 0.85 | ALDH1A1 (0.44) | MAPTCYP1A2CYP2C9CYP2C19NPSR1 | |
| SCHEMBL22809605 | 0.82 | SCN8A (0.47) | SCN8ASCN10ARXFP1MAPTCYP1A2 | |
| SCHEMBL19563618 | 0.82 | SCN8A (0.47) | SCN8ASCN10AMAPTCYP1A2CYP2C9 | |
| SCHEMBL22809656 | 0.82 | HPGD (0.53) | SCN8ASCN10ARXFP1MAPTCYP1A2 | |
| SCHEMBL19524146 | 0.80 | KMT2A (0.49) | SCN8ASCN10AMAPTNPSR1LMNA | |
| SCHEMBL19524139 | 0.80 | SCN8A (0.52) | SCN8ASCN10AALDH1A1 | |
| SCHEMBL957598 | 0.79 | ALDH1A1 (0.41) | SCN8ASCN10ARXFP1MAPTCYP1A2 | |
| SCHEMBL7138558 | 0.77 | LMNA (0.57) | SCN8ASCN10ARXFP1MAPTCYP1A2 | |
| SCHEMBL22809693 | 0.77 | SCN8A (0.48) | SCN8ASCN10AMAPTCYP2C9CYP2C19 | |
| SCHEMBL18570597 | 0.77 | SCN8A (0.48) | SCN8ASCN10ATDP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3239134-B1 | PYRIDONE AMIDES AS MODULATORS OF SODIUM CHANNELS | VERTEX PHARMA (US) | 2020-12-23 | — | — | EP | disclosed |
| EP-2951155-B1 | AMIDES AS MODULATORS OF SODIUM CHANNELS | VERTEX PHARMA (US) | 2019-06-19 | — | — | EP | disclosed |