Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN8A | Q9UQD0 | 2/20 | 0.48 |
| ▸ | SCN10A | Q9Y5Y9 | 2/20 | 0.48 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.40 |
| ▸ | HTT | P42858 | 4/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | ESR1 | P03372 | 1/20 | 0.40 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | PPARD | Q03181 | 1/20 | 0.35 |
| ▸ | PPARA | Q07869 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22809662 | 0.87 | SCN8A (0.46) | SCN8ASCN10ATRPV1ALDH1A1HTT | |
| SCHEMBL955509 | 0.85 | CYP1A1 (0.46) | SCN8ASCN10ATRPV1ALDH1A1HTT | |
| SCHEMBL953869 | 0.84 | PTGDR2 (0.48) | ALDH1A1HTTHPGDSMN1; SMN2POLB | |
| SCHEMBL22090766 | 0.83 | KDM4E (0.45) | SCN8ASCN10AALDH1A1HTTHPGD | |
| SCHEMBL31136545 | 0.82 | ALDH1A1 (0.42) | SCN8ASCN10AALDH1A1HTTHPGD | |
| SCHEMBL957465 | 0.82 | CYP2C19 (0.50) | ALDH1A1HPGDPOLBMAPTKDM4E | |
| SCHEMBL28639293 | 0.81 | ALDH1A1 (0.47) | ALDH1A1HTTHPGDSMN1; SMN2MAPT | |
| SCHEMBL21722870 | 0.80 | APP (0.46) | ALDH1A1HTTHPGDSMN1; SMN2POLB | |
| SCHEMBL22432922 | 0.80 | POLB (0.39) | SCN8ASCN10ATRPV1ALDH1A1HTT | |
| SCHEMBL22090747 | 0.79 | POLB (0.41) | ALDH1A1HTTHPGDSMN1; SMN2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3239134-B1 | PYRIDONE AMIDES AS MODULATORS OF SODIUM CHANNELS | VERTEX PHARMA (US) | 2020-12-23 | — | — | EP | disclosed |