Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | DAO | P14920 | 1/20 | 0.37 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA3 | P07451 | 1/20 | 0.35 |
| ▸ | CA4 | P22748 | 1/20 | 0.35 |
| ▸ | CA6 | P23280 | 1/20 | 0.35 |
| ▸ | CA5A | P35218 | 1/20 | 0.35 |
| ▸ | CA7 | P43166 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.35 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.35 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4704270 | 0.84 | APLNR (0.44) | KDM4EDAONFE2L2POLBRAB9A | |
| SCHEMBL4706111 | 0.82 | KDM4E (0.38) | KDM4EDAONFE2L2POLBMAOB | |
| SCHEMBL21826791 | 0.81 | KDM4E (0.44) | KDM4EDAONFE2L2CA12CA1 | |
| SCHEMBL19550276 | 0.76 | APLNR (0.47) | KDM4ERECQLNFE2L2CA12CA1 | |
| SCHEMBL8337948 | 0.75 | HRH1 (0.47) | DAOMAOBPLAUADRA2AADRA2B | |
| SCHEMBL31497358 | 0.75 | HRH1 (0.47) | DAOMAOBPLAUADRA2AADRA2B | |
| SCHEMBL15769012 | 0.72 | DAO (0.36) | KDM4EDAOMAOBL3MBTL1PLAU | |
| SCHEMBL19555391 | 0.72 | KDM4E (0.45) | KDM4EDAONFE2L2POLBMAOB | |
| SCHEMBL8113789 | 0.71 | RECQL (0.64) | RECQLCA12CA1CA2CA3 | |
| SCHEMBL3553769 | 0.71 | PTK2 (0.40) | KDM4EPOLBRAB9AL3MBTL1ADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3541803-B1 | TRIAZOLE PYRIDYL COMPOUNDS AS AGONISTS OF THE APJ RECEPTOR | AMGEN INC (US) | 2020-12-23 | — | — | EP | disclosed |