Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 3/20 | 0.47 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.46 |
| ▸ | MAOB | P27338 | 4/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.38 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.38 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.38 |
| ▸ | PLAU | P00749 | 1/20 | 0.38 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.38 |
| ▸ | MBOAT4 | Q96T53 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | MTOR | P42345 | 1/20 | 0.35 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.35 |
| ▸ | DAO | P14920 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31497358 | 1.00 | HRH1 (0.47) | HRH1TAAR1MAOBADRA2AADRA2B | |
| SCHEMBL1308116 | 0.82 | — | — | |
| SCHEMBL31398232 | 0.82 | — | — | |
| SCHEMBL15769012 | 0.80 | DAO (0.36) | MAOBADRA2AADRA2BADRA2CPLAU | |
| Hydrochloric Acid SCHEMBL20447607 | 0.80 | ADRA2A (0.42) | MAOBADRA2AADRA2BADRA2CPLAU | |
| Hydrochloric Acid SCHEMBL3493988 | 0.80 | ADRA2A (0.42) | MAOBADRA2AADRA2BADRA2CPLAU | |
| SCHEMBL1312835 | 0.78 | TRPA1 (0.38) | MAOBADRA2AADRA2BADRA2CPLAU | |
| SCHEMBL4705324 | 0.78 | MAOB (0.40) | MAOBADRA2AADRA2BADRA2CPLAU | |
| SCHEMBL3553769 | 0.78 | PTK2 (0.40) | ADRA2AADRA2BADRA2CMBOAT4TSHR | |
| SCHEMBL4705506 | 0.78 | DAO (0.35) | MAOBADRA2AADRA2BADRA2CPLAU |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004024728-A2 | PYRAZOLO[3,4-B]PYRIDINE COMPOUNDS, AND THEIR USE AS PHOSPHODIESTERASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2004-03-25 | — | — | WO | disclosed |