Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 3/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | DGKA | P23743 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4292777 | 0.89 | CYP19A1 (0.49) | CA1CYP19A1ADRA2AADRA1AMAPT | |
| SCHEMBL27822920 | 0.84 | ADRA2A (0.46) | CYP19A1ADRA2AADRA1AMAPTBLM | |
| SCHEMBL25886908 | 0.83 | CA1 (0.44) | CA1CYP19A1ADRA2AADRA1AMAPT | |
| SCHEMBL14308492 | 0.83 | CA1 (0.44) | CA1CYP19A1ADRA2AADRA1AMAPT | |
| SCHEMBL333015 | 0.82 | ADRA2A (0.50) | CA1CYP19A1ADRA2AADRA1AMAPT | |
| SCHEMBL16858300 | 0.82 | CA1 (0.40) | CA1CYP19A1ADRA2AADRA1AMAPT | |
| SCHEMBL2531970 | 0.81 | CA1 (0.43) | CA1CYP19A1ADRA2AADRA1AMAPT | |
| SCHEMBL11051092 | 0.81 | CA1 (0.43) | CA1CYP19A1ADRA2AADRA1AMAPT | |
| SCHEMBL7047744 | 0.81 | DGKA (0.47) | ADRA2AADRA1AMAPTBLML3MBTL1 | |
| SCHEMBL127983 | 0.81 | DGKA (0.47) | CA1CYP19A1ADRA2AADRA1AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3541810-B1 | TRIAZOLE PHENYL COMPOUNDS AS AGONISTS OF THE APJ RECEPTOR | AMGEN INC (US) | 2020-12-23 | — | — | EP | disclosed |