Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | ECE1 | P42892 | 1/20 | 0.35 |
| ▸ | CTSS | P25774 | 1/20 | 0.32 |
| ▸ | CTSK | P43235 | 1/20 | 0.32 |
| ▸ | PSMB5 | P28074 | 2/20 | 0.31 |
| ▸ | MMP3 | P08254 | 1/20 | 0.31 |
| ▸ | MMP9 | P14780 | 1/20 | 0.31 |
| ▸ | MMP8 | P22894 | 1/20 | 0.31 |
| ▸ | MME | P08473 | 1/20 | 0.31 |
| ▸ | ACE | P12821 | 1/20 | 0.31 |
| ▸ | CPA1 | P15085 | 1/20 | 0.31 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.31 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20756387 | 1.00 | ALDH1A1 (0.35) | ALDH1A1LMNAMAPTPTGS2TDP1 | |
| SCHEMBL25869803 | 0.85 | PSMB5 (0.36) | ALDH1A1LMNAMAPTPTGS2TDP1 | |
| SCHEMBL17791875 | 0.85 | ECE1 (0.33) | ALDH1A1LMNAMAPTPTGS2TDP1 | |
| SCHEMBL22695761 | 0.82 | ALDH1A1 (0.36) | ALDH1A1LMNAMAPTPTGS2TDP1 | |
| SCHEMBL3338670 | 0.82 | ALDH1A1 (0.55) | ALDH1A1LMNAMAPTPTGS2TDP1 | |
| SCHEMBL23743699 | 0.82 | ALDH1A1 (0.36) | ALDH1A1LMNAMAPTPTGS2TDP1 | |
| SCHEMBL29697722 | 0.82 | ALDH1A1 (0.55) | ALDH1A1LMNAMAPTPTGS2TDP1 | |
| SCHEMBL17305531 | 0.82 | ALDH1A1 (0.55) | ALDH1A1LMNAMAPTPTGS2TDP1 | |
| SCHEMBL26077042 | 0.80 | ALDH1A1 (0.35) | ALDH1A1LMNAMAPTPTGS2TDP1 | |
| SCHEMBL25672015 | 0.80 | ALDH1A1 (0.35) | ALDH1A1LMNAMAPTPTGS2TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022108992-A9 | PROSTATE-SPECIFIC MEMBRANE ANTIGEN (PSMA)-TARGETED PRODRUG FOR SELECTIVE KILLING OF CELLS EXPRESSING PSMA | THE JOHNS HOPKINS UNIVERSITY (US) | 2023-05-19 | — | — | WO | disclosed |
| WO-2020254602-A1 | CONJUGATES OF AN ELECTRON-DONATING NITROGEN OR TERTIARY AMINE COMPRISING COMPOUNDS | ASCENDIS PHARMA A/S (DK) | 2020-12-24 | — | — | WO | disclosed |
| WO-2020254607-A1 | ANTI-CTLA4 COMPOUNDS WITH LOCALIZED PD PROPERTIES | Ascendis Pharma Oncology Division A/S (DK) | 2020-12-24 | — | — | WO | disclosed |