Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGKA | P23743 | 1/20 | 0.53 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.45 |
| ▸ | PAM | P19021 | 2/20 | 0.41 |
| ▸ | NAAA | Q02083 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | MGLL | Q99685 | 1/20 | 0.40 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.40 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.40 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28496017 | 0.86 | DGKA (0.53) | DGKADNM1PAMNAAAHTR2C | |
| SCHEMBL17882128 | 0.84 | DGKA (0.47) | DGKADNM1NAAAHTR2CPRSS1 | |
| SCHEMBL8334997 | 0.83 | DGKA (0.59) | DGKADNM1PAMNAAAHTR2C | |
| SCHEMBL21028683 | 0.81 | DGKA (0.49) | DGKADNM1PAMHTR2CMGLL | |
| SCHEMBL18799241 | 0.80 | DGKA (0.55) | DGKADNM1PAMNAAAHTR2C | |
| SCHEMBL21008258 | 0.80 | DGKA (0.40) | DGKADNM1PAMNAAAHTR2C | |
| SCHEMBL11820606 | 0.79 | PAM (0.48) | DGKADNM1PAMNAAAMAPT | |
| SCHEMBL28406124 | 0.79 | DGKA (0.48) | DGKADNM1PAMNAAAMAPT | |
| SCHEMBL29258497 | 0.79 | DGKA (0.65) | DGKADNM1PAMNAAAHTR2C | |
| SCHEMBL21007664 | 0.79 | DGKA (0.35) | DGKADNM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020254617-A1 | ANTI-CTLA4 COMPOUNDS WITH LOCALIZED PK PROPERTIES | Ascendis Pharma Oncology Division A/S (DK) | 2020-12-24 | — | — | WO | disclosed |
| WO-2020254607-A1 | ANTI-CTLA4 COMPOUNDS WITH LOCALIZED PD PROPERTIES | Ascendis Pharma Oncology Division A/S (DK) | 2020-12-24 | — | — | WO | disclosed |