Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.49 |
| ▸ | ALPL | P05186 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.47 |
| ▸ | GSK3A | P49840 | 1/20 | 0.45 |
| ▸ | GSK3B | P49841 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | ADCY1 | Q08828 | 1/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.41 |
| ▸ | MET | P08581 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23294484 | 0.84 | KDM4E (0.58) | MAPTALPLNPC1RAB9AKDM4E | |
| SCHEMBL22608589 | 0.82 | KDM4E (0.43) | MAPTALPLNPC1RAB9AKDM4E | |
| Trifluoroacetic Acid SCHEMBL22608586 | 0.78 | KDM4E (0.51) | MAPTALPLNPC1RAB9AKDM4E | |
| SCHEMBL23294291 | 0.76 | HSP90AA1 (0.53) | MAPTALPLKDM4ETP53LMNA | |
| SCHEMBL19715740 | 0.74 | RAB9A (0.48) | MAPTALPLNPC1RAB9AKDM4E | |
| SCHEMBL19669150 | 0.74 | ALDH1A1 (0.53) | MAPTRAB9ATP53LMNAALDH1A1 | |
| SCHEMBL31130227 | 0.73 | MAPT (0.50) | MAPTALPLNPC1RAB9AKDM4E | |
| SCHEMBL9949375 | 0.73 | MAPT (0.59) | MAPTALPLNPC1RAB9AKDM4E | |
| SCHEMBL14886743 | 0.73 | GSK3A (0.58) | MAPTNPC1RAB9AKDM4EGSK3A | |
| SCHEMBL410978 | 0.72 | KDM4E (0.50) | MAPTNPC1RAB9AKDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020257487-A1 | GLYCOLATE OXIDASE INHIBITORS FOR THE TREATMENT OF DISEASE | BIOMARIN PHARMACEUTICAL INC. (US) | 2020-12-24 | — | — | WO | disclosed |