Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | MAOB | P27338 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | AR | P10275 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | DHODH | Q02127 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22818979 | 0.70 | MAPK1 (0.64) | RAB9ANPC1ALOX5ALDH1A1KDM4E | |
| SCHEMBL66437 | 0.66 | PTGS1 (0.42) | RAB9APTGS1MAPTNPC1HTT | |
| SCHEMBL29727510 | 0.66 | NFE2L2 (0.51) | NFE2L2MAPTALDH1A1MAOB | |
| SCHEMBL10630404 | 0.65 | KMT2A (0.50) | RAB9APTGS1MAPTNPC1HTT | |
| SCHEMBL20804472 | 0.63 | ACHE (0.81) | RAB9ANFE2L2PTGS1NPC1ACHE | |
| SCHEMBL422511 | 0.63 | ACHE (0.81) | RAB9ANFE2L2PTGS1NPC1ACHE | |
| SCHEMBL29693877 | 0.63 | APP (0.40) | MAPTHTTALOX5MAOB | |
| SCHEMBL11532298 | 0.62 | NFE2L2 (1.00) | NFE2L2PTGS1ALOX5ACHE | |
| SCHEMBL18240780 | 0.62 | NFE2L2 (0.73) | RAB9ANFE2L2PTGS1NPC1ALOX5 | |
| SCHEMBL11532304 | 0.62 | NFE2L2 (1.00) | NFE2L2PTGS1ALOX5ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020257790-A1 | PHARMACEUTICALLY ACTIVE PYRAZOLO-PYRIDONE MODULATORS OF DCN1/2-MEDIATED CULLIN NEDDYLATION | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) | 2020-12-24 | — | — | WO | disclosed |