Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 3/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | CTNNB1 | P35222 | 4/20 | 0.39 |
| ▸ | TCF7L2 | Q9NQB0 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | CASP1 | P29466 | 2/20 | 0.37 |
| ▸ | CASP7 | P55210 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | TLR8 | Q9NR97 | 4/20 | 0.36 |
| ▸ | TLR7 | Q9NYK1 | 3/20 | 0.36 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.36 |
| ▸ | NOS1 | P29475 | 1/20 | 0.35 |
| ▸ | ELANE | P08246 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29601605 | 1.00 | KCNH2 (0.39) | KCNH2ATMCTNNB1TCF7L2KDM4E | |
| SCHEMBL24384569 | 0.86 | KCNH2 (0.55) | KCNH2TLR8TLR7CYP2D6 | |
| SCHEMBL22959029 | 0.86 | KCNH2 (0.55) | KCNH2TLR8TLR7CYP2D6 | |
| SCHEMBL29601645 | 0.80 | TLR8 (0.47) | KCNH2CTNNB1TCF7L2KDM4ETLR8 | |
| SCHEMBL22819485 | 0.80 | TLR8 (0.47) | KCNH2CTNNB1TCF7L2KDM4ETLR8 | |
| SCHEMBL22958983 | 0.77 | KCNH2 (0.56) | KCNH2TLR8TLR7CYP2D6 | |
| SCHEMBL28698017 | 0.75 | ATM (0.38) | ATMCTNNB1TCF7L2KDM4ECASP1 | |
| SCHEMBL28701677 | 0.70 | TLR8 (0.51) | KCNH2TLR8TLR7RPS6KB1CYP2D6 | |
| SCHEMBL28701678 | 0.70 | TLR8 (0.51) | KCNH2TLR8TLR7RPS6KB1CYP2D6 | |
| SCHEMBL24719004 | 0.69 | TLR8 (0.69) | KCNH2TLR8TLR7CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3986871-B1 | QUINAZOLINE PRODRUGS FOR THE TREATMENT OF VIRAL INFECTIONS AND FURTHER DISEASES | JANSSEN SCIENCES IRELAND UNLIMITED CO (IE) | 2023-06-07 | — | — | EP | disclosed |
| WO-2020254473-A1 | QUINAZOLINE PRODRUGS FOR THE TREATMENT OF VIRAL INFECTIONS AND FURTHER DISEASES | Janssen Sciences Ireland Unlimited Company (IE) | 2020-12-24 | — | — | WO | disclosed |
| WO-2020255019-A1 | COMBINATION OF HEPATITIS B VIRUS (HBV) VACCINES AND A QUINAZOLINE DERIVATIVE | Janssen Sciences Ireland Unlimited Company (IE) | 2020-12-24 | — | — | WO | disclosed |