Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 5/20 | 0.47 |
| ▸ | TLR7 | Q9NYK1 | 5/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | CTNNB1 | P35222 | 2/20 | 0.38 |
| ▸ | TCF7L2 | Q9NQB0 | 2/20 | 0.38 |
| ▸ | CDK1 | P06493 | 1/20 | 0.36 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22819485 | 1.00 | TLR8 (0.47) | TLR8TLR7KCNH2ALDH1A1HPGD | |
| SCHEMBL29601605 | 0.80 | KCNH2 (0.39) | TLR8TLR7KCNH2ALDH1A1HPGD | |
| SCHEMBL22819395 | 0.80 | KCNH2 (0.39) | TLR8TLR7KCNH2ALDH1A1HPGD | |
| SCHEMBL28701678 | 0.80 | TLR8 (0.51) | TLR8TLR7KCNH2CYP2D6RPS6KB1 | |
| SCHEMBL28701677 | 0.80 | TLR8 (0.51) | TLR8TLR7KCNH2CYP2D6RPS6KB1 | |
| SCHEMBL24719004 | 0.79 | TLR8 (0.69) | TLR8TLR7KCNH2CYP2D6 | |
| SCHEMBL21325598 | 0.79 | TLR8 (0.69) | TLR8TLR7KCNH2CYP2D6 | |
| SCHEMBL22819408 | 0.75 | ALDH1A1 (0.50) | ALDH1A1HPGDKDM4EGLAPOLB | |
| SCHEMBL24384569 | 0.72 | KCNH2 (0.55) | TLR8TLR7KCNH2CYP2D6 | |
| SCHEMBL22959029 | 0.72 | KCNH2 (0.55) | TLR8TLR7KCNH2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220324817-A1 | QUINAZOLINE PRODRUGS FOR THE TREATMENT OF VIRAL INFECTIONS AND FURTHER DISEASES | JANSSEN SCIENCES IRELAND UNLMITED COMPANY (IE) | 2022-10-13 | — | — | US | disclosed |
| EP-3986871-A1 | QUINAZOLINE PRODRUGS FOR THE TREATMENT OF VIRAL INFECTIONS AND FURTHER DISEASES | Janssen Sciences Ireland Unlimited Company (IE) | 2022-04-27 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220324817-A1 | QUINAZOLINE PRODRUGS FOR THE TREATMENT OF VIRAL INFECTIONS AND FURTHER DISEASES | IFNG, IRF3, CD4 | TLR8 26/4885TLR7 7/4885KCNH2 3398/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.