Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | GNAI3 | P08754 | 4/20 | 0.43 |
| ▸ | GNAO1 | P09471 | 4/20 | 0.43 |
| ▸ | GNAI1 | P63096 | 4/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6921678 | 1.00 | SMN1; SMN2 (0.48) | SMN1; SMN2GNAI3GNAO1GNAI1HSD11B1 | |
| SCHEMBL24891256 | 0.90 | HSD11B1 (0.46) | SMN1; SMN2GNAI3GNAO1GNAI1HSD11B1 | |
| SCHEMBL13548814 | 0.89 | SMN1; SMN2 (0.45) | SMN1; SMN2GNAI3GNAO1GNAI1HSD11B1 | |
| SCHEMBL13179250 | 0.88 | SMN1; SMN2 (0.41) | SMN1; SMN2GNAI3GNAO1GNAI1HSD11B1 | |
| SCHEMBL13462652 | 0.87 | GNAI3 (0.59) | SMN1; SMN2GNAI3GNAO1GNAI1HSD11B1 | |
| SCHEMBL10080978 | 0.87 | GNAI3 (0.39) | SMN1; SMN2GNAI3GNAO1GNAI1HSD11B1 | |
| SCHEMBL7733573 | 0.87 | HSD11B1 (0.47) | SMN1; SMN2GNAI3GNAO1GNAI1HSD11B1 | |
| SCHEMBL19416662 | 0.86 | SMN1; SMN2 (0.46) | SMN1; SMN2GNAI3GNAO1GNAI1HSD11B1 | |
| SCHEMBL27268804 | 0.85 | SMN1; SMN2 (0.42) | SMN1; SMN2GNAI3GNAO1GNAI1HSD11B1 | |
| SCHEMBL22737188 | 0.84 | SMN1; SMN2 (0.38) | SMN1; SMN2GNAI3GNAO1GNAI1HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020257143-A1 | PYRAZOLOPYRIMIDINE ARYL ETHER INHIBITORS OF JAK KINASES AND USES THEREOF | GENENTECH, INC. (US) | 2020-12-24 | — | — | WO | disclosed |