Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 8/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 6/20 | 0.46 |
| ▸ | F2R | P25116 | 1/20 | 0.40 |
| ▸ | CTSA | P10619 | 1/20 | 0.40 |
| ▸ | NAAA | Q02083 | 2/20 | 0.40 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2229266 | 0.82 | HIF1A (0.47) | USP30HIF1AF2RCTSAPRKAA2 | |
| SCHEMBL2227285 | 0.81 | USP30 (0.68) | USP30HIF1A | |
| SCHEMBL6872823 | 0.80 | HIF1A (0.45) | USP30HIF1AF2RPRKAA2 | |
| SCHEMBL6872132 | 0.78 | KDM5A (0.44) | USP30 | |
| SCHEMBL2227282 | 0.76 | USP30 (0.52) | USP30HIF1ACTSANAAA | |
| SCHEMBL18115672 | 0.76 | USP30 (0.71) | USP30HIF1APRKAA2 | |
| SCHEMBL18115670 | 0.76 | USP30 (0.71) | USP30HIF1APRKAA2 | |
| SCHEMBL29779081 | 0.76 | USP30 (0.81) | USP30 | |
| SCHEMBL16456842 | 0.75 | DGAT1 (0.40) | USP30 | |
| SCHEMBL1929948 | 0.75 | DGAT1 (0.40) | USP30 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011091410-A1 | TRPV4 ANTAGONISTS | GLAXOS SMITHKLINE LLC (US) | 2011-07-28 | — | — | WO | disclosed |
| WO-2011091410-A1 | TRPV4 ANTAGONISTS | GLAXOS SMITHKLINE LLC (US) | 2011-07-28 | — | — | WO | disclosed |