Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.34 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.34 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.34 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | RET | P07949 | 2/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.32 |
| ▸ | EIF2AK4 | Q9P2K8 | 1/20 | 0.31 |
| ▸ | CKS1B | P61024 | 2/20 | 0.31 |
| ▸ | SKP1 | P63208 | 2/20 | 0.31 |
| ▸ | SKP2 | Q13309 | 2/20 | 0.31 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.31 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.30 |
| ▸ | NCF1 | P14598 | 1/20 | 0.30 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22801998 | 1.00 | PDE10A (0.36) | PDE10AAURKAPDPK1AURKBMAP4K4 | |
| SCHEMBL22801999 | 1.00 | PDE10A (0.36) | PDE10AAURKAPDPK1AURKBMAP4K4 | |
| SCHEMBL21285648 | 0.90 | PDE10A (0.36) | PDE10AAURKAPDPK1AURKBMAP4K4 | |
| SCHEMBL22801944 | 0.88 | MAPT (0.38) | PDE10AAURKAPDPK1AURKBPIK3R1 | |
| SCHEMBL21285657 | 0.88 | MAPT (0.38) | PDE10AAURKAPDPK1AURKBPIK3R1 | |
| SCHEMBL21285489 | 0.86 | PDE10A (0.33) | PDE10AAURKAPDPK1AURKBPIK3R1 | |
| SCHEMBL21268782 | 0.85 | GPR119 (0.40) | PDE10AHSD11B1 | |
| SCHEMBL21268784 | 0.85 | GPR119 (0.40) | PDE10AHSD11B1 | |
| SCHEMBL21274050 | 0.82 | PIK3R1 (0.35) | PDE10AAURKAPDPK1AURKBPIK3R1 | |
| SCHEMBL22801937 | 0.82 | PIK3R1 (0.35) | PDE10AAURKAPDPK1AURKBPIK3R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200399268-A1 | Pharmaceutical 6,5 Heterobicyclic Ring Derivatives | EVOTEC (UK) LTD (GB) | 2020-12-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200399268-A1 | Pharmaceutical 6,5 Heterobicyclic Ring Derivatives | STING1, IRF3, NFATC1 | PDE10A 243/4885AURKA 4236/4885PDPK1 719/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.