Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP3 | P42574 | 2/20 | 0.57 |
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.56 |
| ▸ | USP18 | Q9UMW8 | 2/20 | 0.56 |
| ▸ | UCHL5 | Q9Y5K5 | 2/20 | 0.56 |
| ▸ | USP2 | O75604 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 7/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | RAB9A | P51151 | 3/20 | 0.53 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.53 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.53 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22529623 | 1.00 | CASP3 (0.57) | CASP3HSP90AA1USP18UCHL5USP2 | |
| SCHEMBL22529624 | 1.00 | CASP3 (0.57) | CASP3HSP90AA1USP18UCHL5USP2 | |
| SCHEMBL22550893 | 0.92 | CASP3 (0.50) | CASP3HSP90AA1USP18UCHL5USP2 | |
| SCHEMBL22550922 | 0.83 | CYP1A2 (0.60) | MAPTSMN1; SMN2RAB9AMEN1KMT2A | |
| SCHEMBL22823327 | 0.80 | MAPT (0.64) | CASP3USP18UCHL5MAPTSMN1; SMN2 | |
| SCHEMBL22529619 | 0.80 | KMT2A (0.54) | MAPTSMN1; SMN2RAB9AMEN1KMT2A | |
| SCHEMBL22550815 | 0.80 | KMT2A (0.54) | MAPTSMN1; SMN2RAB9AMEN1KMT2A | |
| SCHEMBL22529620 | 0.80 | KMT2A (0.54) | MAPTSMN1; SMN2RAB9AMEN1KMT2A | |
| SCHEMBL22822868 | 0.80 | HSP90AA1 (0.66) | CASP3HSP90AA1USP18UCHL5USP2 | |
| SCHEMBL17885186 | 0.77 | CASP3 (0.91) | CASP3HSP90AA1USP18UCHL5USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200399220-A1 | 3,5-DIARYLIDENYL-N-SUBSTITUTED-PIPERID-4-ONE-DERIVED INHIBITORS OF STAT3 PATHWAY ACTIVITY AND USES THEREOF | KIAKOS KONSTANTINOS (AT) | 2020-12-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200399220-A1 | 3,5-DIARYLIDENYL-N-SUBSTITUTED-PIPERID-4-ONE-DERIVED INHIBITORS OF STAT3 PATHWAY ACTIVITY AND USES THEREOF | STAT3, JAK2, STAT6 | CASP3 85/4885HSP90AA1 1134/4885USP18 3651/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.