Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 2/20 | 0.68 |
| ▸ | LTA4H | P09960 | 4/20 | 0.66 |
| ▸ | HRH3 | Q9Y5N1 | 7/20 | 0.57 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.50 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.50 |
| ▸ | GAK | O14976 | 1/20 | 0.49 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.49 |
| ▸ | JAK2 | O60674 | 1/20 | 0.49 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.49 |
| ▸ | NQO2 | P16083 | 1/20 | 0.49 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.49 |
| ▸ | FECH | P22830 | 1/20 | 0.49 |
| ▸ | JAK1 | P23458 | 1/20 | 0.49 |
| ▸ | TYK2 | P29597 | 1/20 | 0.49 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.49 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29711611 | 0.88 | PRKAB2 (0.57) | BACE1LTA4HKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL18996610 | 0.88 | PRKAB2 (0.57) | BACE1LTA4HKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL22164589 | 0.80 | LTA4H (0.59) | LTA4HHRH3CHRNB2CHRNA4 | |
| SCHEMBL18291218 | 0.79 | LTA4H (0.60) | LTA4HHRH3KDM4ECHRNB2CHRNA4 | |
| SCHEMBL8266135 | 0.78 | BACE1 (0.77) | BACE1LTA4HHRH3KDM4EALDH1A1 | |
| SCHEMBL12439987 | 0.78 | LTA4H (0.62) | BACE1LTA4HHRH3MAP4K4SMN1; SMN2 | |
| SCHEMBL15154833 | 0.78 | LTA4H (0.58) | BACE1LTA4HHRH3MAP4K4KDM4E | |
| SCHEMBL3216190 | 0.77 | LTA4H (0.79) | BACE1LTA4HHRH3KDM4EALDH1A1 | |
| SCHEMBL3209561 | 0.77 | LTA4H (0.79) | BACE1LTA4HHRH3KDM4EALDH1A1 | |
| SCHEMBL14451861 | 0.77 | LTA4H (0.70) | BACE1LTA4HHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11129813-B2 | Antimitotic amides for the treatment of cancer and proliferative disorders | FROST BIOLOGIC, INC. (US) | 2021-09-28 | — | — | US | disclosed |
| US-20200397758-A1 | Antimitotic Amides for the Treatment of Cancer and Proliferative Disorders | FROST BIOLOGIC, INC. | 2020-12-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11129813-B2 | Antimitotic amides for the treatment of cancer and proliferative disorders | CCNA1, CCNE1, CCNB1 | BACE1 4732/4885LTA4H 4486/4885HRH3 105/4885 |
| US-20200397758-A1 | Antimitotic Amides for the Treatment of Cancer and Proliferative Disorders | CCNA1, CCNE1, CCNB1 | BACE1 4732/4885LTA4H 4486/4885HRH3 105/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.