Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSMB5 | P28074 | 20/20 | 0.69 |
| ▸ | PSMB8 | P28062 | 10/20 | 0.69 |
| ▸ | PSMB1 | P20618 | 10/20 | 0.69 |
| ▸ | PSMB9 | P28065 | 9/20 | 0.69 |
| ▸ | PSMB6 | P28072 | 9/20 | 0.69 |
| ▸ | PSMB10 | P40306 | 9/20 | 0.69 |
| ▸ | PSMB2 | P49721 | 9/20 | 0.69 |
| ▸ | PSMB11 | A5LHX3 | 8/20 | 0.69 |
| ▸ | PSMA7 | O14818 | 8/20 | 0.69 |
| ▸ | PSMA1 | P25786 | 8/20 | 0.69 |
| ▸ | PSMA2 | P25787 | 8/20 | 0.69 |
| ▸ | PSMA3 | P25788 | 8/20 | 0.69 |
| ▸ | PSMA4 | P25789 | 8/20 | 0.69 |
| ▸ | PSMA5 | P28066 | 8/20 | 0.69 |
| ▸ | PSMB4 | P28070 | 8/20 | 0.69 |
| ▸ | PSMB3 | P49720 | 8/20 | 0.69 |
| ▸ | PSMA6 | P60900 | 8/20 | 0.69 |
| ▸ | PSMA8 | Q8TAA3 | 8/20 | 0.69 |
| ▸ | PSMB7 | Q99436 | 8/20 | 0.69 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL254186 | 1.00 | PSMB5 (0.69) | PSMB5PSMB8PSMB1PSMB9PSMB6 | |
| SCHEMBL253976 | 0.91 | PSMB5 (0.75) | PSMB5PSMB8PSMB1PSMB9PSMB6 | |
| SCHEMBL22113395 | 0.90 | PSMB5 (0.56) | PSMB5PSMB8PSMB1PSMB9PSMB6 | |
| SCHEMBL10005024 | 0.83 | PSMB5 (0.48) | PSMB5PSMB8PSMB1PSMB9PSMB6 | |
| SCHEMBL4796314 | 0.82 | PSMB5 (0.74) | PSMB5PSMB8PSMB1PSMB9PSMB6 | |
| SCHEMBL4801472 | 0.81 | PSMB5 (0.70) | PSMB5PSMB8PSMB1PSMB9PSMB6 | |
| SCHEMBL4801055 | 0.81 | PSMB5 (0.83) | PSMB5PSMB8PSMB1PSMB9PSMB6 | |
| SCHEMBL253626 | 0.81 | PSMB5 (1.00) | PSMB5PSMB8PSMB1PSMB9PSMB6 | |
| SCHEMBL22832162 | 0.81 | PSMB5 (0.75) | PSMB5PSMB8PSMB1PSMB9PSMB6 | |
| SCHEMBL254225 | 0.81 | PSMB5 (0.75) | PSMB5PSMB8PSMB1PSMB9PSMB6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220017542-A1 | PROTEASOME INHIBITORS | MILLENNIUM PHARMACEUTICALS, INC. | 2022-01-20 | — | — | US | disclosed |
| US-20210206784-A1 | PROTEASOME INHIBITORS | MILLENNIUM PHARMACEUTICALS, INC. | 2021-07-08 | — | — | US | disclosed |
| US-20200407376-A1 | PROTEASOME INHIBITORS | MILLENNIUM PHARMACEUTICALS, INC. | 2020-12-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210206784-A1 | PROTEASOME INHIBITORS | PSMB5, PSMG3, PSMB1 | PSMB5 1/4885PSMB8 32/4885PSMB1 3/4885 |
| US-20220017542-A1 | PROTEASOME INHIBITORS | PSMB5, PSMG3, PSMB1 | PSMB5 1/4885PSMB8 32/4885PSMB1 3/4885 |
| US-20200407376-A1 | PROTEASOME INHIBITORS | PSMB5, PSMG3, PSMB1 | PSMB5 1/4885PSMB8 32/4885PSMB1 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.