SCHEMBL2283241

SCHEMBL2283241

CCCCCCCCc1ccc2c(c1)CCC(C(N)(CO)CO)C2

nearest known ligand 0.76

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
S1PR1 P21453 10/20 0.76
S1PR3 Q99500 7/20 0.76
S1PR4 O95977 4/20 0.76
S1PR5 Q9H228 4/20 0.76
CYP3A4 P08684 1/20 0.60
CYP2C8 P10632 1/20 0.60
CYP2D6 P10635 1/20 0.60
CYP2C9 P11712 1/20 0.60
CYP2C19 P33261 1/20 0.60
TNNC1 P63316 5/20 0.45
SGPL1 O95470 1/20 0.45
GPR183 P32249 1/20 0.45
CERS2 Q96G23 1/20 0.45
PRKD3 O94806 1/20 0.44
PRKCG P05129 1/20 0.44
PRKCB P05771 1/20 0.44
PRKCA P17252 1/20 0.44
PRKCH P24723 1/20 0.44
PRKCI P41743 1/20 0.44
PRKCE Q02156 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13941703 1.00 S1PR1 (0.76) S1PR1S1PR3S1PR4S1PR5CYP3A4
SCHEMBL30530454 1.00 S1PR1 (0.76) S1PR1S1PR3S1PR4S1PR5CYP3A4
SCHEMBL13941698 1.00 S1PR1 (0.76) S1PR1S1PR3S1PR4S1PR5CYP3A4
Bromide SCHEMBL2804849 0.98 S1PR1 (0.73) S1PR1S1PR3S1PR4S1PR5CYP3A4
SCHEMBL5952526 0.95 S1PR1 (0.76) S1PR1S1PR3S1PR4S1PR5CYP3A4
Formic Acid SCHEMBL2809009 0.94 S1PR1 (0.72) S1PR1S1PR3S1PR4S1PR5CYP3A4
SCHEMBL12749389 0.93 S1PR1 (0.67) S1PR1S1PR3S1PR4S1PR5CYP3A4
SCHEMBL14206848 0.93 S1PR1 (0.67) S1PR1S1PR3S1PR4S1PR5CYP3A4
SCHEMBL14206695 0.93 S1PR1 (0.66) S1PR1S1PR3S1PR4S1PR5CYP3A4
SCHEMBL14206696 0.93 S1PR1 (0.66) S1PR1S1PR3S1PR4S1PR5CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2010118298-A2 COMPOSITIONS AND METHODS FOR BIOACTIVE COATINGS TO IMPROVE ALLOGRAFT INCORPORATION UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) 2010-10-14 WO claimed
EP-3054870-B1 COMPRESSED BONE COMPOSITION AND METHODS OF USE THEREOF LIFENET HEALTH (US) 2023-08-16 EP disclosed
US-20230158205-A1 COMPRESSED BONE COMPOSITION AND METHODS OF USE THEREOF LIFENET HEALTH (US) 2023-05-25 US disclosed
US-20230158205-A1 COMPRESSED BONE COMPOSITION AND METHODS OF USE THEREOF LIFENET HEALTH (US) 2023-05-25 US disclosed
US-11576999-B2 Compressed bone composition and methods of use thereof LIFENET HEALTH (US) 2023-02-14 US disclosed
US-20200368391-A1 COMPRESSED BONE COMPOSITION AND METHODS OF USE THEREOF TRUIST BANK 2020-11-26 US disclosed
US-10780196-B2 Compressed bone composition and methods of use thereof LIFENET HEALTH (US) 2020-09-22 US disclosed
US-10780196-B2 Compressed bone composition and methods of use thereof LIFENET HEALTH (US) 2020-09-22 US disclosed
US-10220116-B2 Liquefaction of bone matrix LIFENET HEALTH (US) 2019-03-05 US disclosed
US-9775931-B2 Liquefaction of bone matrix LIFENET HEALTH (US) 2017-10-03 US disclosed
US-20100240617-A1 BICYCLIC SPHINGOSINE 1-PHOSPHATE ANALOGS UNIVERSITY OF VIRGINIA PATENT FOUNDATION 2010-09-23 US disclosed
US-20100240617-A1 BICYCLIC SPHINGOSINE 1-PHOSPHATE ANALOGS UNIVERSITY OF VIRGINIA PATENT FOUNDATION 2010-09-23 US disclosed
US-20100240617-A1 BICYCLIC SPHINGOSINE 1-PHOSPHATE ANALOGS UNIVERSITY OF VIRGINIA PATENT FOUNDATION 2010-09-23 US disclosed
EP-2190852-A1 BICYCLIC SPHINGOSINE 1-PHOSPHATE ANALOGS University Of Virginia Patent Foundation (US) 2010-06-02 EP disclosed
WO-2009023854-A1 BICYCLIC SPHINGOSINE 1-PHOSPHATE ANALOGS UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) 2009-02-19 WO disclosed
WO-2009023854-A1 BICYCLIC SPHINGOSINE 1-PHOSPHATE ANALOGS UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) 2009-02-19 WO disclosed
US-20090042955-A1 BICYCLIC SPHINGOSINE 1-PHOSPHATE ANALOGS UNIVERSITY OF VIRGINIA PATENT FOUNDATION 2009-02-12 US disclosed
US-20090042955-A1 BICYCLIC SPHINGOSINE 1-PHOSPHATE ANALOGS UNIVERSITY OF VIRGINIA PATENT FOUNDATION 2009-02-12 US disclosed
US-20090042955-A1 BICYCLIC SPHINGOSINE 1-PHOSPHATE ANALOGS UNIVERSITY OF VIRGINIA PATENT FOUNDATION 2009-02-12 US disclosed
WO-2007092638-A1 BICYCLIC SPHINGOSINE 1-PHOSPHATE ANALOGS UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) 2007-08-16 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090042955-A1 BICYCLIC SPHINGOSINE 1-PHOSPHATE ANALOGS S1PR1, S1PR4, S1PR3 S1PR1 1/4885S1PR3 3/4885S1PR4 2/4885
US-10220116-B2 Liquefaction of bone matrix BMP2, BMP4, MATR3 S1PR1 2590/4885S1PR3 1814/4885S1PR4 1664/4885
US-20100240617-A1 BICYCLIC SPHINGOSINE 1-PHOSPHATE ANALOGS S1PR1, S1PR4, S1PR3 S1PR1 1/4885S1PR3 3/4885S1PR4 2/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.