Acetamide

Acetamide

SCHEMBL2283407

CC(N)=O.CCC(CC)(C(=O)O)C(=O)O

nearest known ligand 0.44

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALOX15 P16050 2/20 0.44
LMNA P02545 1/20 0.44
BLM P54132 1/20 0.44
PMP22 Q01453 1/20 0.44
ALDH1A1 P00352 3/20 0.38
MEN1 O00255 2/20 0.38
CYP1A2 P05177 2/20 0.38
KMT2A Q03164 2/20 0.38
THRB P10828 1/20 0.38
FFAR3 O14843 2/20 0.33
TDP1 Q9NUW8 2/20 0.33
GRM2 Q14416 1/20 0.33
GRM3 Q14832 1/20 0.33
ARG1 P05089 1/20 0.32
ARG2 P78540 1/20 0.32
TSHR P16473 2/20 0.32
ACHE P22303 1/20 0.32
NOS3 P29474 1/20 0.32
NOS1 P29475 1/20 0.32
NOS2 P35228 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL51201 0.88 FFAR3 (0.41) ALDH1A1MEN1CYP1A2KMT2ATHRB
SCHEMBL28746064 0.85 FFAR3 (0.39) ALDH1A1MEN1CYP1A2KMT2ATHRB
Hydrochloric Acid SCHEMBL8053454 0.85 FFAR3 (0.39) ALDH1A1MEN1CYP1A2KMT2ATHRB
SCHEMBL11203689 0.85 FFAR3 (0.39) ALDH1A1MEN1CYP1A2KMT2ATHRB
SCHEMBL9489101 0.85 FFAR3 (0.39) ALDH1A1MEN1CYP1A2KMT2ATHRB
SCHEMBL3673385 0.85 ALDH1A1 (0.39) ALDH1A1MEN1CYP1A2KMT2ATHRB
SCHEMBL17818653 0.85 FFAR3 (0.39) ALDH1A1MEN1CYP1A2KMT2ATHRB
SCHEMBL104624 0.85 FFAR3 (0.39) ALDH1A1MEN1CYP1A2KMT2ATHRB
SCHEMBL4382923 0.85 FFAR3 (0.39) ALDH1A1MEN1CYP1A2KMT2ATHRB
SCHEMBL4882973 0.85 FFAR3 (0.39) ALDH1A1MEN1CYP1A2KMT2ATHRB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8173710-B2 Bicyclic sphingosine 1-phosphate analogs UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) 2012-05-08 US disclosed
US-20110195936-A1 BICYCLIC SPHINGOSINE 1-PHOSPHATE ANALOGS UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) 2011-08-11 US disclosed
US-20100240617-A1 BICYCLIC SPHINGOSINE 1-PHOSPHATE ANALOGS UNIVERSITY OF VIRGINIA PATENT FOUNDATION 2010-09-23 US disclosed
EP-2190852-A1 BICYCLIC SPHINGOSINE 1-PHOSPHATE ANALOGS University Of Virginia Patent Foundation (US) 2010-06-02 EP disclosed
WO-2009023854-A1 BICYCLIC SPHINGOSINE 1-PHOSPHATE ANALOGS UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) 2009-02-19 WO disclosed
US-20090042955-A1 BICYCLIC SPHINGOSINE 1-PHOSPHATE ANALOGS UNIVERSITY OF VIRGINIA PATENT FOUNDATION 2009-02-12 US disclosed
EP-1987013-A1 BICYCLIC SPHINGOSINE 1-PHOSPHATE ANALOGS UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) 2008-11-05 EP disclosed
WO-2007092638-A1 BICYCLIC SPHINGOSINE 1-PHOSPHATE ANALOGS UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) 2007-08-16 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090042955-A1 BICYCLIC SPHINGOSINE 1-PHOSPHATE ANALOGS S1PR1, S1PR4, S1PR3 ALOX15 2800/4885LMNA 2761/4885BLM 4159/4885
US-20110195936-A1 BICYCLIC SPHINGOSINE 1-PHOSPHATE ANALOGS S1PR1, S1PR4, S1PR3 ALOX15 2800/4885LMNA 2761/4885BLM 4159/4885
US-20100240617-A1 BICYCLIC SPHINGOSINE 1-PHOSPHATE ANALOGS S1PR1, S1PR4, S1PR3 ALOX15 2800/4885LMNA 2761/4885BLM 4159/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.