Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 3/20 | 0.72 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.72 |
| ▸ | FLT3 | P36888 | 1/20 | 0.60 |
| ▸ | ABCG2 | Q9UNQ0 | 4/20 | 0.60 |
| ▸ | SLC5A1 | P13866 | 1/20 | 0.54 |
| ▸ | SLC5A2 | P31639 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.52 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.50 |
| ▸ | DPP4 | P27487 | 1/20 | 0.50 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.50 |
| ▸ | RELA | Q04206 | 1/20 | 0.50 |
| ▸ | CXCL12 | P48061 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.48 |
| ▸ | MAOA | P21397 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2283541 | 1.00 | TP53 (0.72) | TP53MDM2FLT3ABCG2SLC5A1 | |
| SCHEMBL2284259 | 0.91 | FLT3 (0.73) | TP53MDM2FLT3ABCG2SLC5A1 | |
| SCHEMBL2284249 | 0.91 | FLT3 (0.73) | TP53MDM2FLT3ABCG2SLC5A1 | |
| SCHEMBL2283498 | 0.90 | FLT3 (0.61) | TP53MDM2FLT3ABCG2SLC5A1 | |
| SCHEMBL30383403 | 0.90 | NFKB1 (0.63) | TP53MDM2FLT3ABCG2SLC5A1 | |
| SCHEMBL2286892 | 0.90 | NFKB1 (0.63) | TP53MDM2FLT3ABCG2SLC5A1 | |
| SCHEMBL2283509 | 0.90 | FLT3 (0.61) | TP53MDM2FLT3ABCG2SLC5A1 | |
| SCHEMBL2286904 | 0.90 | NFKB1 (0.63) | TP53MDM2FLT3ABCG2SLC5A1 | |
| SCHEMBL2282340 | 0.89 | FLT3 (0.60) | TP53MDM2FLT3ABCG2SLC5A1 | |
| SCHEMBL2283524 | 0.89 | FLT3 (0.60) | TP53MDM2FLT3ABCG2SLC5A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9061984-B2 | Compounds related to chalcones and benzothienopyrimidines, their synthesis, and uses to treat diseases | UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC. (US) | 2015-06-23 | — | — | US | disclosed |
| US-20110190325-A1 | COMPOUNDS, THEIR SYNTHESES, AND THIER USES | THE JOHNS HOPKINS UNIVERSITY | 2011-08-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110190325-A1 | COMPOUNDS, THEIR SYNTHESES, AND THIER USES | TERT, TYMS, NISCH | TP53 396/4885MDM2 1890/4885FLT3 213/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.