Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.48 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.48 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
| ▸ | PRNP | P04156 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2592561 | 0.91 | CSNK2A2 (0.51) | CSNK2A2CSNK2BCSNK2A1ALDH1A1KDM4E | |
| SCHEMBL30406117 | 0.91 | CSNK2A2 (0.51) | CSNK2A2CSNK2BCSNK2A1ALDH1A1KDM4E | |
| SCHEMBL19604833 | 0.81 | KMT2A (0.45) | ALDH1A1KDM4EKMT2AMAPTMAPK1 | |
| SCHEMBL2571973 | 0.77 | KMT2A (0.46) | CSNK2A2CSNK2BCSNK2A1ALDH1A1KMT2A | |
| SCHEMBL944312 | 0.70 | POLB (0.72) | ALDH1A1KDM4EKMT2AMAPTMEN1 | |
| SCHEMBL14916139 | 0.69 | KMT2A (0.50) | CSNK2A2CSNK2BCSNK2A1ALDH1A1KDM4E | |
| SCHEMBL2554433 | 0.68 | NPC1 (0.69) | ALDH1A1MAPTMAPK1CYP1A2CYP3A4 | |
| SCHEMBL30406237 | 0.68 | NPC1 (0.69) | ALDH1A1MAPTMAPK1CYP1A2CYP3A4 | |
| SCHEMBL16181940 | 0.68 | ALDH1A1 (0.70) | ALDH1A1KDM4EKMT2AMAPTMAPK1 | |
| Hydrochloric Acid SCHEMBL7084627 | 0.66 | MAPT (0.54) | CSNK2A2CSNK2BCSNK2A1ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3799870-A1 | IRE-1A INHIBITORS | Fosun Orinove Pharmatech, Inc. (CN) | 2021-04-07 | — | — | EP | disclosed |
| EP-3409276-B1 | IRE-1A INHIBITORS | FOSUN ORINOVE PHARMATECH INC (CN) | 2020-12-30 | — | — | EP | disclosed |