Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | FPR2 | P25090 | 2/20 | 0.44 |
| ▸ | MPO | P05164 | 1/20 | 0.43 |
| ▸ | ENPP1 | P22413 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | CLK1 | P49759 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | FPR1 | P21462 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30406117 | 0.90 | CSNK2A2 (0.51) | KMT2ASMN1; SMN2FPR2ALDH1A1HPGD | |
| SCHEMBL2592561 | 0.90 | CSNK2A2 (0.51) | KMT2ASMN1; SMN2FPR2ALDH1A1HPGD | |
| SCHEMBL2571973 | 0.89 | KMT2A (0.46) | KMT2AFPR2MPOENPP1ALDH1A1 | |
| SCHEMBL22840417 | 0.81 | CSNK2A2 (0.48) | KMT2ASMN1; SMN2ALDH1A1LMNAHPGD | |
| SCHEMBL14916139 | 0.72 | KMT2A (0.50) | KMT2AALDH1A1HPGDALOX15MAPK1 | |
| SCHEMBL2568967 | 0.70 | ALDH1A1 (0.53) | SMN1; SMN2ALDH1A1LMNAHPGDKDM4E | |
| SCHEMBL2570516 | 0.68 | ALDH1A1 (0.41) | KMT2ASMN1; SMN2ALDH1A1HPGDKDM4E | |
| SCHEMBL14930174 | 0.67 | ERN1 (0.51) | KMT2ASMN1; SMN2ALDH1A1LMNAHPGD | |
| SCHEMBL20687573 | 0.66 | ENPP1 (0.61) | FPR2ENPP1 | |
| SCHEMBL16198383 | 0.62 | ENPP1 (0.57) | FPR2ENPP1PRMT5LMNAWDR77 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170326104-A1 | IRE-1ALPHA INHIBITORS | FOSUN ORINOVE PHARMATECH, INC. (CN) | 2017-11-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170326104-A1 | IRE-1ALPHA INHIBITORS | ERN1, XBP1, ERN2 | KMT2A 4481/4885SMN1; SMN2 952/4885FPR2 3884/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.