Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 6/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.58 |
| ▸ | TP53 | P04637 | 1/20 | 0.58 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | ACHE | P22303 | 1/20 | 0.52 |
| ▸ | CA12 | O43570 | 1/20 | 0.52 |
| ▸ | CA1 | P00915 | 1/20 | 0.52 |
| ▸ | CA2 | P00918 | 1/20 | 0.52 |
| ▸ | CA7 | P43166 | 1/20 | 0.52 |
| ▸ | CA9 | Q16790 | 1/20 | 0.52 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.52 |
| ▸ | GRM5 | P41594 | 1/20 | 0.51 |
| ▸ | SLC22A12 | Q96S37 | 2/20 | 0.51 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.49 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17425007 | 0.83 | HPGD (0.68) | HPGDALDH1A1TP53NPC1RAB9A | |
| SCHEMBL13503971 | 0.79 | GRM5 (0.69) | HPGDALDH1A1TP53NPC1RAB9A | |
| SCHEMBL10722678 | 0.77 | ACHE (0.82) | HPGDALDH1A1TP53NPC1RAB9A | |
| SCHEMBL13503967 | 0.77 | ACHE (0.61) | HPGDALDH1A1TP53NPC1RAB9A | |
| SCHEMBL10724144 | 0.75 | ACHE (0.77) | HPGDALDH1A1TP53NPC1RAB9A | |
| SCHEMBL18475959 | 0.75 | ACHE (0.72) | HPGDALDH1A1TP53NPC1RAB9A | |
| SCHEMBL14028160 | 0.74 | HPGD (1.00) | HPGDALDH1A1TP53NPC1RAB9A | |
| SCHEMBL14270437 | 0.74 | GLA (0.60) | HPGDALDH1A1TP53NPC1RAB9A | |
| SCHEMBL4512023 | 0.73 | NPC1 (0.76) | HPGDALDH1A1TP53NPC1RAB9A | |
| SCHEMBL12217964 | 0.73 | ALDH1A1 (0.55) | HPGDALDH1A1TP53NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3535267-B1 | [1,2,4]TRIAZOLO[1,5-A]PYRIMIDINE DERIVATIVES AS PDE2 INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2020-12-30 | — | — | EP | disclosed |