Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 5/20 | 0.44 |
| ▸ | HPGD | P15428 | 4/20 | 0.43 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.43 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
| ▸ | MTOR | P42345 | 1/20 | 0.40 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.40 |
| ▸ | PHGDH | O43175 | 1/20 | 0.39 |
| ▸ | CDK1 | P06493 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | CDK9 | P50750 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | F2 | P00734 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14930122 | 0.71 | ERN1 (0.59) | ERN1HPGDPIN1RIPK1HDAC4 | |
| SCHEMBL10720943 | 0.66 | PHGDH (0.81) | HPGDPHGDHMAPTKMT2A | |
| SCHEMBL1662915 | 0.65 | PHGDH (0.65) | ERN1HPGDPHGDHMAPTKMT2A | |
| SCHEMBL2786906 | 0.65 | HPGD (0.73) | ERN1HPGDPHGDHJAK2HRH3 | |
| SCHEMBL4908920 | 0.64 | RIPK1 (0.55) | HPGDPIN1RIPK1HDAC4PIK3CA | |
| SCHEMBL17645897 | 0.64 | RIPK1 (0.55) | HPGDPIN1RIPK1HDAC4PIK3CA | |
| SCHEMBL2199279 | 0.63 | PHGDH (0.71) | HPGDPHGDHMAPTKMT2A | |
| SCHEMBL26475623 | 0.63 | PHGDH (0.64) | HPGDHDAC4PHGDHJAK2F2 | |
| SCHEMBL5401495 | 0.63 | HPGD (0.48) | ERN1HPGDRIPK1PHGDHJAK2 | |
| SCHEMBL8150805 | 0.62 | HPGD (0.76) | HPGDPHGDHMAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3409276-B1 | IRE-1A INHIBITORS | FOSUN ORINOVE PHARMATECH INC (CN) | 2020-12-30 | — | — | EP | disclosed |