Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPAS1 | Q99814 | 2/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.32 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | RHEB | Q15382 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22842920 | 0.88 | SCN8A (0.38) | EPAS1KMT2ASCN8ASCN10AALDH1A1 | |
| SCHEMBL22842865 | 0.87 | THRB (0.36) | THRBCYP3A4KMT2ASCN8ASCN10A | |
| SCHEMBL22842870 | 0.87 | THRB (0.36) | EPAS1THRBCYP3A4SCN8ASCN10A | |
| SCHEMBL22842857 | 0.81 | RPS6KA1 (0.35) | THRBKMT2AMAPT | |
| SCHEMBL22842860 | 0.80 | EPAS1 (0.36) | EPAS1THRBSCN8ASCN10AMAPK1 | |
| SCHEMBL22832147 | 0.79 | GRM6 (0.36) | EPAS1 | |
| SCHEMBL22842880 | 0.79 | KCNA3 (0.36) | THRBCYP3A4GAAMAPK1RXFP1 | |
| SCHEMBL22842859 | 0.78 | SCN8A (0.36) | EPAS1SCN8ASCN10AGAAMAPK1 | |
| SCHEMBL22842881 | 0.78 | KCNA3 (0.35) | EPAS1THRBKMT2ASCN8ASCN10A | |
| SCHEMBL22842858 | 0.77 | KCNA3 (0.36) | THRBGAAMAPK1RXFP1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020261156-A1 | QUINAZOLIN-4-ONE DERIVATIVES USEFUL FOR THE TREATMENT OF BRAF-ASSOCIATED DISEASES AND DISORDERS | ARRAY BIOPHARMA INC. (US) | 2020-12-30 | — | — | WO | disclosed |