Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA3 | P22001 | 2/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | CRHBP | P24387 | 1/20 | 0.33 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | MAOB | P27338 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | CISD2 | Q8N5K1 | 1/20 | 0.31 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.31 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.30 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.30 |
| ▸ | PKM | P14618 | 1/20 | 0.30 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22842864 | 0.89 | KCNA3 (0.34) | KCNA3THRBMAPTGAAMAPK1 | |
| SCHEMBL22842858 | 0.86 | KCNA3 (0.36) | KCNA3THRBKDM4EMAPTCRHBP | |
| SCHEMBL22842865 | 0.81 | THRB (0.36) | KCNA3THRBMAPTGAAMAPK1 | |
| SCHEMBL22842870 | 0.81 | THRB (0.36) | KCNA3THRBGAAMAPK1CISD2 | |
| SCHEMBL22842867 | 0.79 | EPAS1 (0.36) | THRBMAPTGAAMAPK1CYP3A4 | |
| SCHEMBL22842881 | 0.79 | KCNA3 (0.35) | KCNA3THRBKDM4ECISD2PKM | |
| SCHEMBL22842857 | 0.76 | RPS6KA1 (0.35) | THRBKDM4EMAPTCRHBPCRHR2 | |
| SCHEMBL22842883 | 0.76 | EPAS1 (0.37) | KCNA3THRBKDM4EMAPTGAA | |
| SCHEMBL22842863 | 0.75 | SLC22A12 (0.38) | KCNA3MAPTMAPK1PKMRXFP1 | |
| SCHEMBL22842859 | 0.73 | SCN8A (0.36) | KCNA3GAAMAPK1PKMRXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020261156-A1 | QUINAZOLIN-4-ONE DERIVATIVES USEFUL FOR THE TREATMENT OF BRAF-ASSOCIATED DISEASES AND DISORDERS | ARRAY BIOPHARMA INC. (US) | 2020-12-30 | — | — | WO | disclosed |