Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | CA1 | P00915 | 3/20 | 0.46 |
| ▸ | CA2 | P00918 | 3/20 | 0.46 |
| ▸ | CA12 | O43570 | 2/20 | 0.46 |
| ▸ | CA3 | P07451 | 2/20 | 0.46 |
| ▸ | CA4 | P22748 | 2/20 | 0.46 |
| ▸ | CA6 | P23280 | 2/20 | 0.46 |
| ▸ | CA5A | P35218 | 2/20 | 0.46 |
| ▸ | CA7 | P43166 | 2/20 | 0.46 |
| ▸ | CA9 | Q16790 | 2/20 | 0.46 |
| ▸ | CA13 | Q8N1Q1 | 2/20 | 0.46 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.46 |
| ▸ | CA5B | Q9Y2D0 | 2/20 | 0.46 |
| ▸ | KIF11 | P52732 | 1/20 | 0.44 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.42 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2284914 | 0.85 | SMN1; SMN2 (0.56) | SMN1; SMN2LMNAHTTALDH1A1GAA | |
| SCHEMBL2373111 | 0.81 | SMN1; SMN2 (0.63) | SMN1; SMN2LMNAHTTALDH1A1GAA | |
| SCHEMBL9978287 | 0.79 | SMN1; SMN2 (0.66) | SMN1; SMN2LMNAHTTALDH1A1GAA | |
| SCHEMBL17431601 | 0.79 | F2 (0.36) | HTTALDH1A1CA1CA2CA9 | |
| SCHEMBL17431639 | 0.77 | LMNA (0.42) | SMN1; SMN2LMNAHTTALDH1A1CA1 | |
| SCHEMBL2371771 | 0.77 | SMN1; SMN2 (0.63) | SMN1; SMN2LMNAHTTALDH1A1GAA | |
| SCHEMBL17431596 | 0.76 | CA1 (0.39) | HTTALDH1A1CA1CA2CA9 | |
| SCHEMBL17907417 | 0.74 | SMN1; SMN2 (1.00) | SMN1; SMN2LMNAHTTALDH1A1GAA | |
| SCHEMBL27170892 | 0.73 | SMN1; SMN2 (0.73) | SMN1; SMN2LMNAHTTALDH1A1GAA | |
| SCHEMBL2279182 | 0.73 | SMN1; SMN2 (0.58) | SMN1; SMN2LMNAHTTALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2523559-A1 | COMPOUNDS AND METHODS | GlaxoSmithKline LLC (US) | 2012-11-21 | — | — | EP | claimed |
| WO-2011088027-A1 | COMPOUNDS AND METHODS | GLAXOSMITHKLINE LLC (US) | 2011-07-21 | — | — | WO | claimed |
| EP-2523559-A1 | COMPOUNDS AND METHODS | GlaxoSmithKline LLC (US) | 2012-11-21 | — | — | EP | disclosed |
| WO-2011088027-A1 | COMPOUNDS AND METHODS | GLAXOSMITHKLINE LLC (US) | 2011-07-21 | — | — | WO | disclosed |