Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTHFD2 | P13995 | 1/20 | 0.34 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.32 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | PARP1 | P09874 | 1/20 | 0.32 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.32 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.31 |
| ▸ | KDR | P35968 | 1/20 | 0.31 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.31 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22845519 | 0.94 | MTHFD2 (0.35) | MTHFD2PTK2SCN9ABRD4CREBBP | |
| SCHEMBL22845506 | 0.93 | S1PR2 (0.34) | PTK2LRRK2BRD4CREBBPALDH1A1 | |
| SCHEMBL22845412 | 0.91 | MAPT (0.41) | ALDH1A1POLBKDRHDAC6 | |
| SCHEMBL22845388 | 0.90 | PREP (0.35) | MTHFD2BRD4MAPK14HDAC1HDAC10 | |
| SCHEMBL22845340 | 0.89 | PRLHR (0.35) | MTHFD2ALDH1A1 | |
| SCHEMBL22845264 | 0.89 | PRLHR (0.35) | MTHFD2ALDH1A1 | |
| SCHEMBL24483838 | 0.88 | HDAC1 (0.35) | MTHFD2ALDH1A1PARP1PARP2P2RX7 | |
| SCHEMBL24173491 | 0.87 | ITGB2 (0.33) | MTHFD2ALDH1A1PARP1PARP2P2RX7 | |
| SCHEMBL22845373 | 0.86 | TP53 (0.35) | MTHFD2PTK2ALDH1A1KDM4EPOLB | |
| SCHEMBL22845206 | 0.84 | POLB (0.41) | ALDH1A1POLBDYRK1AHDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220000874-A1 | TRICYCLIC COMPOUNDS | ALIGOS THERAPEUTICS, INC. | 2022-01-06 | — | — | US | disclosed |
| US-11136321-B2 | Tricyclic compounds | ALIGOS THERAPEUTICS, INC. (US) | 2021-10-05 | — | — | US | disclosed |
| US-20200407361-A1 | TRICYCLIC COMPOUNDS | ALIGOS THERAPEUTICS, INC. | 2020-12-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220000874-A1 | TRICYCLIC COMPOUNDS | SLC10A1, PKD1, CEL | MTHFD2 2383/4885PTK2 4823/4885SCN9A 765/4885 |
| US-11136321-B2 | Tricyclic compounds | SLC10A1, PKD1, CEL | MTHFD2 2383/4885PTK2 4823/4885SCN9A 765/4885 |
| US-20200407361-A1 | TRICYCLIC COMPOUNDS | SLC10A1, PKD1, CEL | MTHFD2 2383/4885PTK2 4823/4885SCN9A 765/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.