Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC7A5 | Q01650 | 4/20 | 0.77 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.71 |
| ▸ | ALPI | P09923 | 1/20 | 0.71 |
| ▸ | PKM | P14618 | 1/20 | 0.71 |
| ▸ | XIAP | P98170 | 1/20 | 0.71 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.54 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.53 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.53 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.53 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.53 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | USP2 | O75604 | 1/20 | 0.53 |
| ▸ | EGFR | P00533 | 1/20 | 0.53 |
| ▸ | LCK | P06239 | 1/20 | 0.53 |
| ▸ | FYN | P06241 | 1/20 | 0.53 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.53 |
| ▸ | HTR2A | P28223 | 1/20 | 0.53 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tyrosine SCHEMBL28019917 | 1.00 | SLC7A5 (0.77) | SLC7A5PTGS1ALPIPKMXIAP | |
| Tyrosine SCHEMBL28049225 | 0.97 | SLC7A5 (0.77) | SLC7A5PTGS1ALPIPKMXIAP | |
| Tyrosine SCHEMBL4301284 | 0.95 | SLC7A5 (0.86) | SLC7A5PTGS1ALPIPKMXIAP | |
| Tyrosine SCHEMBL20703797 | 0.95 | SLC7A5 (0.86) | SLC7A5PTGS1ALPIPKMXIAP | |
| Tyrosine SCHEMBL4629448 | 0.95 | SLC7A5 (0.86) | SLC7A5PTGS1ALPIPKMXIAP | |
| Tyrosine SCHEMBL9937710 | 0.95 | SLC7A5 (0.86) | SLC7A5PTGS1ALPIPKMXIAP | |
| Tyrosine SCHEMBL10804023 | 0.95 | SLC7A5 (0.86) | SLC7A5PTGS1ALPIPKMXIAP | |
| Phenylalanine SCHEMBL9539848 | 0.94 | SLC7A5 (0.69) | SLC7A5PTGS1ALPIPKMXIAP | |
| Tyrosine SCHEMBL27542577 | 0.94 | SLC7A5 (0.69) | SLC7A5PTGS1ALPIPKMXIAP | |
| Tyrosine SCHEMBL5699043 | 0.93 | SLC7A5 (0.89) | SLC7A5PTGS1ALPIPKMXIAP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030148932-A1 | Compounds that bind to p185 and methods of using the same | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2003-08-07 | — | — | US | claimed |
| WO-2003045309-A2 | Peptides, peptide compositions,and methods of use in binding p 185 | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2003-06-05 | — | — | WO | claimed |
| US-10323062-B2 | Pharmaceutical composition for the prevention and treatment of cardiovascular disease comprising the peptide having the ability to inhibit angiotensin-1 converting enzyme as an active ingredient | UNIVERSITY-INDUSTRY COOPERATION GROUP OF KYUNG HEE UNIVERSITY (KR) | 2019-06-18 | — | — | US | disclosed |
| US-10308681-B2 | Pharmaceutical composition for the prevention and treatment of cardiovascular disease comprising the peptide having the ability to inhibit angiotensin-1 converting enzyme as an active ingredient | UNIVERSITY-INDUSTRY COOPERATION GROUP OF KYUNG HEE UNIVERSITY (KR) | 2019-06-04 | — | — | US | disclosed |
| US-20180170961-A1 | PHARMACEUTICAL COMPOSITION FOR THE PREVENTION AND TREATMENT OF CARDIOVASCULAR DISEASE COMPRISING THE PEPTIDE HAVING THE ABILITY TO INHIBIT ANGIOTENSIN-1 CONVERTING ENZYME AS AN ACTIVE INGREDIENT | UNIVERSITY-INDUSTRY COOPERATION GROUP OF KYUNG HEE UNIVERSITY (KR) | 2018-06-21 | — | — | US | disclosed |
| US-20150175654-A1 | PHARMACEUTICAL COMPOSITION FOR THE PREVENTION AND TREATMENT OF CARDIOVASCULAR DISEASE COMPRISING THE PEPTIDE HAVING THE ABILITY TO INHIBIT ANGIOTENSIN-1 CONVERTING ENZYME AS AN ACTIVE INGREDIENT | UNIVERSITY-INDUSTRY COOPERATION GROUP OF KYUNG HEE UNIVERSITY (KR) | 2015-06-25 | — | — | US | disclosed |
| US-7998924-B2 | Compounds that bind to p185 and methods of using the same | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2011-08-16 | — | — | US | disclosed |
| US-20100311669-A1 | COMPOUNDS THAT BIND TO P185 AND METHODS OF USING THE SAME | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2010-12-09 | — | — | US | disclosed |
| US-7745577-B2 | Compounds that bind to P185 and methods of using the same | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2010-06-29 | — | — | US | disclosed |
| US-20070207086-A1 | Compounds that bind to P185 and methods of using the same | UNIVERSITY OF PENNSYLVANIA (US) | 2007-09-06 | — | — | US | disclosed |
| US-7179785-B2 | Compounds that bind to p185 and methods of using the same | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2007-02-20 | — | — | US | disclosed |
| US-20030148932-A1 | Compounds that bind to p185 and methods of using the same | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2003-08-07 | — | — | US | disclosed |
| WO-2003045309-A2 | Peptides, peptide compositions,and methods of use in binding p 185 | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2003-06-05 | — | — | WO | disclosed |