Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSTP1 | P09211 | 1/20 | 0.40 |
| ▸ | GSTM2 | P28161 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | PRNP | P04156 | 2/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.37 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.36 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | FGB | P02675 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31053008 | 0.84 | MEN1 (0.32) | GSTP1GSTM2KMT2AALDH1A1MEN1 | |
| SCHEMBL29238689 | 0.82 | GSTP1 (0.38) | GSTP1GSTM2KMT2APOLBPRNP | |
| SCHEMBL24660012 | 0.77 | CCNC (0.42) | KMT2AALDH1A1HSD17B10MAPTLMNA | |
| SCHEMBL21852192 | 0.77 | GSTP1 (0.42) | GSTP1GSTM2KMT2APOLBPRNP | |
| SCHEMBL30660933 | 0.76 | KMT2A (0.43) | GSTP1GSTM2KMT2APOLBPRNP | |
| SCHEMBL18320494 | 0.76 | KMT2A (0.43) | GSTP1GSTM2KMT2APOLBPRNP | |
| SCHEMBL21855915 | 0.76 | CXCR1 (0.42) | GSTP1GSTM2KMT2APOLBPRNP | |
| SCHEMBL29506185 | 0.76 | CXCR1 (0.42) | GSTP1GSTM2KMT2APOLBPRNP | |
| SCHEMBL22848251 | 0.76 | CCNB2 (0.39) | KMT2APOLBPRNPRXFP1ALDH1A1 | |
| SCHEMBL21855732 | 0.74 | GSTP1 (0.43) | GSTP1GSTM2KMT2APOLBPRNP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114008037-B | Heterocyclic compounds as KRAS G12C inhibitors | 广东新契生物医药科技有限公司 | 2024-06-21 | — | — | CN | disclosed |
| US-20220153741-A1 | HETEROCYCLIC COMPOUNDS AS INHIBITORS OF KRAS G12C | GUANGDONG NEWOPP BIOPHARMACEUTICALS CO., LTD. (CN) | 2022-05-19 | — | — | US | disclosed |
| CN-114008037-A | Heterocyclic compounds as KRAS G12C inhibitors | 广东新契生物医药科技有限公司 | 2022-02-01 | — | — | CN | disclosed |
| WO-2020259513-A1 | HETEROCYCLIC COMPOUNDS AS INHIBITORS OF KRAS G12C | GUANGDONG NEWOPP BIOPHARMACEUTICALS CO., LTD. (CN) | 2020-12-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220153741-A1 | HETEROCYCLIC COMPOUNDS AS INHIBITORS OF KRAS G12C | KRAS, NRAS, HRAS | GSTP1 2752/4885GSTM2 2997/4885KMT2A 1219/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.