Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | GGPS1 | O95749 | 1/20 | 0.37 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.36 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | DAO | P14920 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25884436 | 0.89 | CTSD (0.39) | KDM4ETSHRMEN1KMT2AHDAC4 | |
| SCHEMBL23806488 | 0.86 | KDM4E (0.36) | KDM4ETSHRSMN1; SMN2ALDH1A1HDAC4 | |
| SCHEMBL23568943 | 0.83 | HDAC4 (0.41) | KDM4ETSHRSMN1; SMN2RAB9ACYP4F2 | |
| SCHEMBL14200520 | 0.82 | CTSD (0.43) | KDM4ETSHRSMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL27535907 | 0.81 | LPL (0.46) | KDM4ESMN1; SMN2RAB9AALDH1A1HDAC4 | |
| SCHEMBL10154614 | 0.80 | KDM4E (0.41) | KDM4ETSHRSMN1; SMN2ALDH1A1HDAC4 | |
| SCHEMBL14234021 | 0.80 | CYP4F2 (0.43) | KDM4ETSHRSMN1; SMN2RAB9AGGPS1 | |
| SCHEMBL27657598 | 0.80 | LPL (0.53) | — | |
| SCHEMBL13416681 | 0.78 | KDM4E (0.39) | KDM4ETSHRSMN1; SMN2ALDH1A1HDAC4 | |
| SCHEMBL2464423 | 0.78 | LPL (0.54) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020264499-A1 | IRAK DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2020-12-30 | — | — | WO | disclosed |