SCHEMBL22852011

SCHEMBL22852011

O=C(Nc1ccccc1NC(=O)c1cccc(=O)n1O)C1=CC=CC(=O)C1O

nearest known ligand 0.45

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
IDH1 O75874 1/20 0.45
MMP1 P03956 1/20 0.39
MMP3 P08254 1/20 0.39
MMP7 P09237 1/20 0.39
MMP9 P14780 1/20 0.39
MMP8 P22894 1/20 0.39
MMP12 P39900 1/20 0.39
MMP13 P45452 1/20 0.39
HDAC4 P56524 1/20 0.30
HDAC1 Q13547 1/20 0.30
HDAC7 Q8WUI4 1/20 0.30
HDAC2 Q92769 1/20 0.30
HDAC8 Q9BY41 1/20 0.30
HDAC6 Q9UBN7 1/20 0.30
HDAC9 Q9UKV0 1/20 0.30
HDAC5 Q9UQL6 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22852019 0.81 IDH1 (0.66) IDH1MMP1MMP3MMP7MMP9
SCHEMBL22852085 0.72 IDH1 (0.62) IDH1MMP1MMP3MMP7MMP9
SCHEMBL38651962 0.72 IDH1 (0.61) IDH1MMP1MMP3MMP7MMP9
SCHEMBL38651963 0.68 IDH1 (0.64) IDH1MMP1MMP3MMP7MMP9
SCHEMBL20202476 0.68
SCHEMBL29793822 0.68 IDH1 (0.68) IDH1MMP1MMP3MMP7MMP9
SCHEMBL13531433 0.66 IDH1 (0.66) IDH1MMP1MMP3MMP7MMP9
SCHEMBL13469162 0.66 IDH1 (0.70) IDH1MMP1MMP3MMP7MMP9
SCHEMBL29446621 0.64 MMP1 (0.64) IDH1MMP1MMP3MMP7MMP9
SCHEMBL38652064 0.64 IDH1 (0.57) IDH1MMP1MMP3MMP7MMP9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2020263761-A1 IRON(III) AND GALLIUM(III) METAL ORGANIC POLYHEDRA, METHODS OF MAKING SAME, AND USES THEREOF THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (US) 2020-12-30 WO disclosed