Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAS2R14 | Q9NYV8 | 2/20 | 0.50 |
| ▸ | CFTR | P13569 | 1/20 | 0.50 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.42 |
| ▸ | DHODH | Q02127 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | CES2 | O00748 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | LIPC | P11150 | 1/20 | 0.39 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | MPO | P05164 | 1/20 | 0.38 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30294444 | 1.00 | TAS2R14 (0.50) | TAS2R14CFTRMRGPRX4DHODHKDM4E | |
| SCHEMBL29383454 | 0.87 | CFTR (0.50) | TAS2R14CFTRMRGPRX4DHODHMCL1 | |
| SCHEMBL22833864 | 0.87 | CFTR (0.50) | TAS2R14CFTRMRGPRX4DHODHMCL1 | |
| SCHEMBL22852835 | 0.87 | TAS2R14 (0.62) | TAS2R14MRGPRX4DHODHLIPCLIPG | |
| SCHEMBL30294708 | 0.87 | TAS2R14 (0.62) | TAS2R14MRGPRX4DHODHLIPCLIPG | |
| SCHEMBL26930895 | 0.85 | CFTR (0.48) | TAS2R14CFTRMRGPRX4KDM4EHPGD | |
| SCHEMBL22853086 | 0.85 | CFTR (0.50) | TAS2R14CFTRMRGPRX4DHODHKDM4E | |
| SCHEMBL22853395 | 0.84 | DHODH (0.49) | TAS2R14CFTRDHODHKDM4EHPGD | |
| SCHEMBL30294511 | 0.84 | DHODH (0.49) | TAS2R14CFTRDHODHKDM4EHPGD | |
| SCHEMBL22852810 | 0.82 | CFTR (0.48) | TAS2R14CFTRDHODHKDM4ECES2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020261114-A1 | 2,3-DIHYDROQUINAZOLIN COMPOUNDS AS NAV1.8 INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2020-12-30 | — | — | WO | disclosed |